Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.12688/f1000research.11295.1 http://scihub22266oqcxt.onion/10.12688/f1000research.11295.1 C5464225!5464225!28649369     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       F1000Res 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28649369|t=2017. Recent advances in understanding contextual TGF? signaling |pdf=|usr=}}{{28649369}} gab.com Text Recent advances in understanding contextual TGF signaling JO: F1000Res http://www.kidney.de/pget.php?&tw=1&pmid=28649369 #FOAvip The appearance of the first animal species on earth coincides with the emergence of transforming growth factor ? (TGF?) pathways. The evolution of these animals into more complex organisms coincides with a progressively increased TGF? repertoire through gene duplications and divergence, making secreted TGF? molecules the largest family of morphogenetic proteins in humans. It is therefore not surprising that TGF? pathways govern numerous aspects of human biology from early embryonic development to regeneration, hematopoiesis, neurogenesis, and immunity. Such heavy reliance on these pathways is reflected in the susceptibility to minor perturbations in pathway components that can lead to dysregulated signaling and a diverse range of human pathologies such as cancer, fibrosis, and developmental disorders. Attempts to comprehensively resolve these signaling cascades are complicated by the long-recognized paradoxical role the pathway plays in cell biology. Recently, several groups have probed examples of the disparate aspects of TGF? biology in a variety of animal models and uncovered novel context-dependent regulatory mechanisms. Here, we briefly review recent advancements and discuss their overall impact in directing future TGF? research. Twit Text FOAVip Recent advances in understanding contextual TGF signaling ????F1000Res http://www.kidney.de/pget.php?&tw=1&pmid=28649369 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28649369 #FOAvip English Wikipedia <ref>{{Cite pmid|28649369}}</ref> Recent advances in understanding contextual TGF? signaling #MMPMID28649369 Ayyaz A; Attisano L; Wrana JL F1000Res 2017[]; 6 (ä): ä PMID28649369show ga The appearance of the first animal species on earth coincides with the emergence of transforming growth factor ? (TGF?) pathways. The evolution of these animals into more complex organisms coincides with a progressively increased TGF? repertoire through gene duplications and divergence, making secreted TGF? molecules the largest family of morphogenetic proteins in humans. It is therefore not surprising that TGF? pathways govern numerous aspects of human biology from early embryonic development to regeneration, hematopoiesis, neurogenesis, and immunity. Such heavy reliance on these pathways is reflected in the susceptibility to minor perturbations in pathway components that can lead to dysregulated signaling and a diverse range of human pathologies such as cancer, fibrosis, and developmental disorders. Attempts to comprehensively resolve these signaling cascades are complicated by the long-recognized paradoxical role the pathway plays in cell biology. Recently, several groups have probed examples of the disparate aspects of TGF? biology in a variety of animal models and uncovered novel context-dependent regulatory mechanisms. Here, we briefly review recent advancements and discuss their overall impact in directing future TGF? research. äRecent advances in understanding contextual TGF? signaling (epmc).pdf DeepDyve Pubget Overpricing