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10.12688/f1000research.11034.1 http://scihub22266oqcxt.onion/10.12688/f1000research.11034.1 C5464219!5464219!28649368     free     free     free       F1000Res 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28649368|t=2017. Wnt target genes and where to find them |pdf=|usr=}}{{28649368}} gab.com Text Wnt target genes and where to find them JO: F1000Res http://www.kidney.de/pget.php?&tw=1&pmid=28649368 #FOAvip Wnt/?-catenin signaling is highly conserved throughout metazoans, is required for numerous essential events in development, and serves as a stem cell niche signal in many contexts. Misregulation of the pathway is linked to several human pathologies, most notably cancer. Wnt stimulation results in stabilization and nuclear import of ?-catenin, which then acts as a transcriptional co-activator. Transcription factors of the T-cell family (TCF) are the best-characterized nuclear binding partners of ?-catenin and mediators of Wnt gene regulation. This review provides an update on what is known about the transcriptional activation of Wnt target genes, highlighting recent work that modifies the conventional model. Wnt/?-catenin signaling regulates genes in a highly context-dependent manner, and the role of other signaling pathways and TCF co-factors in this process will be discussed. Understanding Wnt gene regulation has served to elucidate many biological roles of the pathway, and we will use examples from stem cell biology, metabolism, and evolution to illustrate some of the rich Wnt biology that has been uncovered. Twit Text FOAVip Wnt target genes and where to find them ????F1000Res http://www.kidney.de/pget.php?&tw=1&pmid=28649368 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28649368 #FOAvip English Wikipedia <ref>{{Cite pmid|28649368}}</ref> Wnt target genes and where to find them #MMPMID28649368 Ramakrishnan AB; Cadigan KM F1000Res 2017[]; 6 (ä): ä PMID28649368show ga Wnt/?-catenin signaling is highly conserved throughout metazoans, is required for numerous essential events in development, and serves as a stem cell niche signal in many contexts. Misregulation of the pathway is linked to several human pathologies, most notably cancer. Wnt stimulation results in stabilization and nuclear import of ?-catenin, which then acts as a transcriptional co-activator. Transcription factors of the T-cell family (TCF) are the best-characterized nuclear binding partners of ?-catenin and mediators of Wnt gene regulation. This review provides an update on what is known about the transcriptional activation of Wnt target genes, highlighting recent work that modifies the conventional model. Wnt/?-catenin signaling regulates genes in a highly context-dependent manner, and the role of other signaling pathways and TCF co-factors in this process will be discussed. Understanding Wnt gene regulation has served to elucidate many biological roles of the pathway, and we will use examples from stem cell biology, metabolism, and evolution to illustrate some of the rich Wnt biology that has been uncovered. äWnt target genes and where to find them (epmc).pdf DeepDyve Pubget Overpricing