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10.1186/s13054-017-1731-0 http://scihub22266oqcxt.onion/10.1186/s13054-017-1731-0 C5463395!5463395!28592328     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Crit+Care 2017 ; 21 (ä): ä Nephropedia Template TP {{tp|p=28592328|t=2017. Severe varicella-zoster virus pneumonia: a multicenter cohort study |pdf=|usr=}}{{28592328}} gab.com Text Severe varicella-zoster virus pneumonia: a multicenter cohort study JO: Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=28592328 #FOAvip Background: Pneumonia is a dreaded complication of varicella-zoster virus (VZV) infection in adults; however, the data are limited. Our objective was to investigate the clinical features, management, and outcomes of critically ill patients with VZV-related community-acquired pneumonia (VZV-CAP). Methods: This was an observational study of patients with VZV-CAP admitted to 29 intensive care units (ICUs) from January 1996 to January 2015. Results: One hundred and two patients with VZV-CAP were included. Patients were young (age 39 years (interquartile range 32?51)) and 53 (52%) were immunocompromised. Time since respiratory symptom onset was 2 (1?3) days. There was a seasonal distribution of the disease, with more cases during spring and winter time. All but four patients presented with typical skin rash on ICU admission. Half the patients received mechanical ventilation within 1 (1?2) day following ICU admission (the ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FiO2)?=?150 (80?284), 80% with acute respiratory distress syndrome (ARDS)). Sequential Organ Failure Assessment (SOFA) score on day 1 (odds ratio (OR) 1.90 (1.33?2.70); p?<?0.001), oxygen flow at ICU admission (OR 1.25 (1.08?1.45); p?=?0.004), and early bacterial co-infection (OR 14.94 (2.00?111.8); p?=?0.009) were independently associated with the need for mechanical ventilation. Duration of mechanical ventilation was 14 (7?21) days. ICU and hospital mortality rates were 17% and 24%, respectively. All patients were treated with aciclovir and 10 received adjunctive therapy with steroids. Compared to 60 matched steroid-free controls, patients treated with steroids had a longer mechanical ventilation duration, ICU length of stay, and a similar hospital mortality, but experienced more ICU-acquired infections. Conclusions: Severe VZV-CAP is responsible for an acute pulmonary involvement associated with a significant morbidity and mortality. Steroid therapy did not influence mortality, but increased the risk of superinfection. Electronic supplementary material: The online version of this article (doi:10.1186/s13054-017-1731-0) contains supplementary material, which is available to authorized users. Twit Text FOAVip Severe varicella-zoster virus pneumonia: a multicenter cohort study ????Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=28592328 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28592328 #FOAvip English Wikipedia <ref>{{Cite pmid|28592328}}</ref> Severe varicella-zoster virus pneumonia: a multicenter cohort study #MMPMID28592328 Mirouse A; Vignon P; Piron P; Robert R; Papazian L; Géri G; Blanc P; Guitton C; Guérin C; Bigé N; Rabbat A; Lefebvre A; Razazi K; Fartoukh M; Mariotte E; Bouadma L; Ricard JD; Seguin A; Souweine B; Moreau AS; Faguer S; Mari A; Mayaux J; Schneider F; Stoclin A; Perez P; Maizel J; Lafon C; Ganster F; Argaud L; Girault C; Barbier F; Lecuyer L; Lambert J; Canet E Crit Care 2017[]; 21 (ä): ä PMID28592328show ga Background: Pneumonia is a dreaded complication of varicella-zoster virus (VZV) infection in adults; however, the data are limited. Our objective was to investigate the clinical features, management, and outcomes of critically ill patients with VZV-related community-acquired pneumonia (VZV-CAP). Methods: This was an observational study of patients with VZV-CAP admitted to 29 intensive care units (ICUs) from January 1996 to January 2015. Results: One hundred and two patients with VZV-CAP were included. Patients were young (age 39 years (interquartile range 32?51)) and 53 (52%) were immunocompromised. Time since respiratory symptom onset was 2 (1?3) days. There was a seasonal distribution of the disease, with more cases during spring and winter time. All but four patients presented with typical skin rash on ICU admission. Half the patients received mechanical ventilation within 1 (1?2) day following ICU admission (the ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FiO2)?=?150 (80?284), 80% with acute respiratory distress syndrome (ARDS)). Sequential Organ Failure Assessment (SOFA) score on day 1 (odds ratio (OR) 1.90 (1.33?2.70); p? äSevere varicella-zoster virus pneumonia: a multicenter cohort study (epmc).pdf DeepDyve Pubget Overpricing