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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Oxid+Med+Cell+Longev 2017 ; 2017 (ä): ä Nephropedia Template TP
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NADPH Oxidases: Insights into Selected Functions and Mechanisms of Action in Cancer and Stem Cells #MMPMID28626501
Skonieczna M; Hejmo T; Poterala-Hejmo A; Cieslar-Pobuda A; Buldak RJ
Oxid Med Cell Longev 2017[]; 2017 (ä): ä PMID28626501show ga
NADPH oxidases (NOX) are reactive oxygen species- (ROS-) generating enzymes regulating numerous redox-dependent signaling pathways. NOX are important regulators of cell differentiation, growth, and proliferation and of mechanisms, important for a wide range of processes from embryonic development, through tissue regeneration to the development and spread of cancer. In this review, we discuss the roles of NOX and NOX-derived ROS in the functioning of stem cells and cancer stem cells and in selected aspects of cancer cell physiology. Understanding the functions and complex activities of NOX is important for the application of stem cells in tissue engineering, regenerative medicine, and development of new therapies toward invasive forms of cancers.