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10.7554/eLife.24603 http://scihub22266oqcxt.onion/10.7554/eLife.24603 C5462544!5462544!28500756     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28500756|t=2017. Sphingomyelin metabolism controls the shape and function of the Golgi cisternae |pdf=|usr=}}{{28500756}} gab.com Text Sphingomyelin metabolism controls the shape and function of the Golgi cisternae JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=28500756 #FOAvip The flat Golgi cisterna is a highly conserved feature of eukaryotic cells, but how is this morphology achieved and is it related to its function in cargo sorting and export? A physical model of cisterna morphology led us to propose that sphingomyelin (SM) metabolism at the trans-Golgi membranes in mammalian cells essentially controls the structural features of a Golgi cisterna by regulating its association to curvature-generating proteins. An experimental test of this hypothesis revealed that affecting SM homeostasis converted flat cisternae into highly curled membranes with a concomitant dissociation of membrane curvature-generating proteins. These data lend support to our hypothesis that SM metabolism controls the structural organization of a Golgi cisterna. Together with our previously presented role of SM in controlling the location of proteins involved in glycosylation and vesicle formation, our data reveal the significance of SM metabolism in the structural organization and function of Golgi cisternae.DOI:http://dx.doi.org/10.7554/eLife.24603.001 Twit Text FOAVip Sphingomyelin metabolism controls the shape and function of the Golgi cisternae ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=28500756 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28500756 #FOAvip English Wikipedia <ref>{{Cite pmid|28500756}}</ref> Sphingomyelin metabolism controls the shape and function of the Golgi cisternae #MMPMID28500756 Campelo F; van Galen J; Turacchio G; Parashuraman S; Kozlov MM; García-Parajo MF; Malhotra V eLife 2017[]; 6 (ä): ä PMID28500756show ga The flat Golgi cisterna is a highly conserved feature of eukaryotic cells, but how is this morphology achieved and is it related to its function in cargo sorting and export? A physical model of cisterna morphology led us to propose that sphingomyelin (SM) metabolism at the trans-Golgi membranes in mammalian cells essentially controls the structural features of a Golgi cisterna by regulating its association to curvature-generating proteins. An experimental test of this hypothesis revealed that affecting SM homeostasis converted flat cisternae into highly curled membranes with a concomitant dissociation of membrane curvature-generating proteins. These data lend support to our hypothesis that SM metabolism controls the structural organization of a Golgi cisterna. Together with our previously presented role of SM in controlling the location of proteins involved in glycosylation and vesicle formation, our data reveal the significance of SM metabolism in the structural organization and function of Golgi cisternae.DOI:http://dx.doi.org/10.7554/eLife.24603.001 äSphingomyelin metabolism controls the shape and function of the Golgi (epmc).pdf DeepDyve Pubget Overpricing