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10.1080/23723556.2017.1311827

http://scihub22266oqcxt.onion/10.1080/23723556.2017.1311827
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C5462520!5462520!28616586
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suck abstract from ncbi


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pmid28616586      Mol+Cell+Oncol 2017 ; 4 (3): ä
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  • The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer #MMPMID28616586
  • Erstad DJ; Tager AM; Hoshida Y; Fuchs BC
  • Mol Cell Oncol 2017[]; 4 (3): ä PMID28616586show ga
  • Using transcriptome meta-analysis, we recently identified the autotaxin (ATX)-lysophosphatidic acid (LPA) pathway as a regulator of hepatocellular carcinoma (HCC) risk in human cirrhosis patients. Pharmacological targeting of this pathway reduced fibrosis progression and HCC development in animals, identifying ATX-LPA signaling as a novel chemoprevention strategy for cirrhosis and HCC.
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