Senescent cells: New target for an old treatment? #MMPMID28616578
Demaria M
Mol Cell Oncol 2017[]; 4 (3): ä PMID28616578show ga
Many genotoxic chemotherapies have debilitating side effects and induce cellular senescence in normal tissues. Senescent cells acquire a pro-inflammatory phenotype which contributes to local and systemic inflammation. Eliminating senescent cells reduce several short- and long-term effects of the drugs, providing a new target to reduce the toxicity of anticancer treatments.