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10.1080/15384101.2017.1312237 http://scihub22266oqcxt.onion/10.1080/15384101.2017.1312237 C5462088!5462088!28388267     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Cycle 2017 ; 16 (10): 999-1007 Nephropedia Template TP {{tp|p=28388267|t=2017. Activation of Notch pathway is linked with epithelial-mesenchymal transition in prostate cancer cells |pdf=|usr=}}{{28388267}} gab.com Text Activation of Notch pathway is linked with epithelial-mesenchymal transition in prostate cancer cells JO: Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=28388267 #FOAvip Notch signaling has been reported to play an essential role in tumorigenesis. Several studies have suggested that Notch receptors could be oncoproteins or tumor suppressors in different types of human cancers. Emerging evidence has suggested that Notch pathway regulates cell growth, apoptosis, cell cycle, and metastasis. In the current study, we explore whether Notch-1 could regulate the cell invasion and migration as well as EMT (epithelial-mesenchymal transition) in prostate cancer cells. We found that overexpression of Notch-1 enhanced cell migration and invasion in PC-3 cells. However, downregulation of Notch-1 retarded cell migration and invasion in prostate cancer cells. Importantly, we observed that overexpression of Notch-1 led to EMT in PC-3 cells. Notably, we found that EMT-type cells are associated with EMT markers change and cancer stem cell phenotype. Taken together, we concluded that downregulation of Notch-1 could be a promising approach for inhibition of invasion in prostate cancer cells, which could be useful for the treatment of metastatic prostate cancer. Twit Text FOAVip Activation of Notch pathway is linked with epithelial-mesenchymal transition in prostate cancer cells ????Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=28388267 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28388267 #FOAvip English Wikipedia <ref>{{Cite pmid|28388267}}</ref> Activation of Notch pathway is linked with epithelial-mesenchymal transition in prostate cancer cells #MMPMID28388267 Zhang L; Sha J; Yang G; Huang X; Bo J; Huang Y Cell Cycle 2017[]; 16 (10): 999-1007 PMID28388267show ga Notch signaling has been reported to play an essential role in tumorigenesis. Several studies have suggested that Notch receptors could be oncoproteins or tumor suppressors in different types of human cancers. Emerging evidence has suggested that Notch pathway regulates cell growth, apoptosis, cell cycle, and metastasis. In the current study, we explore whether Notch-1 could regulate the cell invasion and migration as well as EMT (epithelial-mesenchymal transition) in prostate cancer cells. We found that overexpression of Notch-1 enhanced cell migration and invasion in PC-3 cells. However, downregulation of Notch-1 retarded cell migration and invasion in prostate cancer cells. Importantly, we observed that overexpression of Notch-1 led to EMT in PC-3 cells. Notably, we found that EMT-type cells are associated with EMT markers change and cancer stem cell phenotype. Taken together, we concluded that downregulation of Notch-1 could be a promising approach for inhibition of invasion in prostate cancer cells, which could be useful for the treatment of metastatic prostate cancer. äActivation of Notch pathway is linked with epithelial-mesenchymal tran(epmc).pdf DeepDyve Pubget Overpricing