Activation of Notch pathway is linked with epithelial-mesenchymal transition in
prostate cancer cells
#MMPMID28388267
Zhang L
; Sha J
; Yang G
; Huang X
; Bo J
; Huang Y
Cell Cycle
2017[May]; 16
(10
): 999-1007
PMID28388267
show ga
Notch signaling has been reported to play an essential role in tumorigenesis.
Several studies have suggested that Notch receptors could be oncoproteins or
tumor suppressors in different types of human cancers. Emerging evidence has
suggested that Notch pathway regulates cell growth, apoptosis, cell cycle, and
metastasis. In the current study, we explore whether Notch-1 could regulate the
cell invasion and migration as well as EMT (epithelial-mesenchymal transition) in
prostate cancer cells. We found that overexpression of Notch-1 enhanced cell
migration and invasion in PC-3 cells. However, downregulation of Notch-1 retarded
cell migration and invasion in prostate cancer cells. Importantly, we observed
that overexpression of Notch-1 led to EMT in PC-3 cells. Notably, we found that
EMT-type cells are associated with EMT markers change and cancer stem cell
phenotype. Taken together, we concluded that downregulation of Notch-1 could be a
promising approach for inhibition of invasion in prostate cancer cells, which
could be useful for the treatment of metastatic prostate cancer.
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