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10.1002/prp2.293 http://scihub22266oqcxt.onion/10.1002/prp2.293 C5461643!5461643!28596841     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28596841&cmd=llinks): Failed to open stream: HTTP request failed! 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Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases |pdf=|usr=}}{{28596841}} gab.com Text Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases JO: Pharmacol Res Perspect http://www.kidney.de/pget.php?&tw=1&pmid=28596841 #FOAvip Emerging viruses such as HIV, dengue, influenza A, SARS coronavirus, Ebola, and other viruses pose a significant threat to human health. Majority of these viruses are responsible for the outbreaks of pathogenic lethal infections. To date, there are no effective therapeutic strategies available for the prophylaxis and treatment of these infections. Chloroquine analogs have been used for decades as the primary and most successful drugs against malaria. Concomitant with the emergence of chloroquine?resistant Plasmodium strains and a subsequent decrease in the use as antimalarial drugs, other applications of the analogs have been investigated. Since the analogs have interesting biochemical properties, these drugs are found to be effective against a wide variety of viral infections. As antiviral action, the analogs have been shown to inhibit acidification of endosome during the events of replication and infection. Moreover, immunomodulatory effects of analogs have been beneficial to patients with severe inflammatory complications of several viral diseases. Interestingly, one of the successful targeting strategies is the inhibition of HIV replication by the analogs in vitro which are being tested in several clinical trials. This review focuses on the potentialities of chloroquine analogs for the treatment of endosomal low pH dependent emerging viral diseases. Twit Text FOAVip Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases ????Pharmacol Res Perspect http://www.kidney.de/pget.php?&tw=1&pmid=28596841 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28596841 #FOAvip English Wikipedia <ref>{{Cite pmid|28596841}}</ref> Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases #MMPMID28596841 Al?Bari MAA Pharmacol Res Perspect 2017[Feb]; 5 (1): ä PMID28596841show ga Emerging viruses such as HIV, dengue, influenza A, SARS coronavirus, Ebola, and other viruses pose a significant threat to human health. Majority of these viruses are responsible for the outbreaks of pathogenic lethal infections. To date, there are no effective therapeutic strategies available for the prophylaxis and treatment of these infections. Chloroquine analogs have been used for decades as the primary and most successful drugs against malaria. Concomitant with the emergence of chloroquine?resistant Plasmodium strains and a subsequent decrease in the use as antimalarial drugs, other applications of the analogs have been investigated. Since the analogs have interesting biochemical properties, these drugs are found to be effective against a wide variety of viral infections. As antiviral action, the analogs have been shown to inhibit acidification of endosome during the events of replication and infection. Moreover, immunomodulatory effects of analogs have been beneficial to patients with severe inflammatory complications of several viral diseases. Interestingly, one of the successful targeting strategies is the inhibition of HIV replication by the analogs in vitro which are being tested in several clinical trials. This review focuses on the potentialities of chloroquine analogs for the treatment of endosomal low pH dependent emerging viral diseases. äTargeting endosomal acidification by chloroquine analogs as a promisin(epmc).pdf DeepDyve Pubget Overpricing