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2017 ; 5
(1
): e00293
Nephropedia Template TP
gab.com Text
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English Wikipedia
Targeting endosomal acidification by chloroquine analogs as a promising strategy
for the treatment of emerging viral diseases
#MMPMID28596841
Al-Bari MAA
Pharmacol Res Perspect
2017[Feb]; 5
(1
): e00293
PMID28596841
show ga
Emerging viruses such as HIV, dengue, influenza A, SARS coronavirus, Ebola, and
other viruses pose a significant threat to human health. Majority of these
viruses are responsible for the outbreaks of pathogenic lethal infections. To
date, there are no effective therapeutic strategies available for the prophylaxis
and treatment of these infections. Chloroquine analogs have been used for decades
as the primary and most successful drugs against malaria. Concomitant with the
emergence of chloroquine-resistant Plasmodium strains and a subsequent decrease
in the use as antimalarial drugs, other applications of the analogs have been
investigated. Since the analogs have interesting biochemical properties, these
drugs are found to be effective against a wide variety of viral infections. As
antiviral action, the analogs have been shown to inhibit acidification of
endosome during the events of replication and infection. Moreover,
immunomodulatory effects of analogs have been beneficial to patients with severe
inflammatory complications of several viral diseases. Interestingly, one of the
successful targeting strategies is the inhibition of HIV replication by the
analogs in vitro which are being tested in several clinical trials. This review
focuses on the potentialities of chloroquine analogs for the treatment of
endosomal low pH dependent emerging viral diseases.
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