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2017 ; 31
(3
): 403-407
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Correlation Between Expression of the Cancer/Testis Antigen KK-LC-1 and
Helicobacter pylori Infection in Gastric Cancer
#MMPMID28438869
Fukuyama T
; Futawatari N
; Ichiki Y
; Shida A
; Yamazaki T
; Nishi Y
; Nonoguchi H
; Takahashi Y
; Yamazaki H
; Kobayashi N
In Vivo
2017[May]; 31
(3
): 403-407
PMID28438869
show ga
BACKGROUND/AIM: Our previous study indicated that Kita-kyushu lung cancer
antigen-1 (KK-LC-1) is a cancer/testis antigen (CTA) expressed in 82% of gastric
cancer cases. Here, we investigated the relationship between KK-LC-1 expression
and Helicobacter pylori infection in Japanese patients with gastric cancer.
PATIENTS AND METHODS: We examined CTA expression in 25 surgical gastric cancer
specimens and anti-H. pylori IgGs in the serum of each patient. RESULTS: KK-LC-1
was expressed in 80% of tumor samples, markedly higher than melanoma antigen gene
(MAGE)-A1, MAGE-A3, MAGE-A4, synovial sarcoma, X breakpoint 4 (SSX4) and New York
esophageal squamous cell carcinoma-1 (NY-ESO-1). Anti-H. pylori IgG titers from
the KK-LC-1-positive patients were significantly higher (67.5±7.6) than those
from KK-LC-1-negative patients (15.8±7.5, p<0.01) although there were no
significant differences between patients positive and negative for MAGE-A1, -A3
and-A4, SSX4 and NY-ESO-1. CONCLUSION: As far as we are aware, this is the first
report of a correlation between a carcinogen and CTA expression in clinical
samples. KK-LC-1 was frequently expressed in gastric cancer caused by H. pylori
infection. The risk diagnosis for gastric cancer might be more accurate if
KK-LC-1 expression status were also considered.
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