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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Math+Neurosci
2017 ; 7
(1
): 3
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Timescales and Mechanisms of Sigh-Like Bursting and Spiking in Models of Rhythmic
Respiratory Neurons
#MMPMID28589465
Wang Y
; Rubin JE
J Math Neurosci
2017[Dec]; 7
(1
): 3
PMID28589465
show ga
Neural networks generate a variety of rhythmic activity patterns, often involving
different timescales. One example arises in the respiratory network in the
pre-Bötzinger complex of the mammalian brainstem, which can generate the eupneic
rhythm associated with normal respiration as well as recurrent low-frequency,
large-amplitude bursts associated with sighing. Two competing hypotheses have
been proposed to explain sigh generation: the recruitment of a neuronal
population distinct from the eupneic rhythm-generating subpopulation or the
reconfiguration of activity within a single population. Here, we consider two
recent computational models, one of which represents each of the hypotheses. We
use methods of dynamical systems theory, such as fast-slow decomposition,
averaging, and bifurcation analysis, to understand the multiple-timescale
mechanisms underlying sigh generation in each model. In the course of our
analysis, we discover that a third timescale is required to generate sighs in
both models. Furthermore, we identify the similarities of the underlying
mechanisms in the two models and the aspects in which they differ.