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10.1186/s13321-017-0220-4 http://scihub22266oqcxt.onion/10.1186/s13321-017-0220-4 C5461230/?report=reader!5461230!29086040     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cheminform 2017 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29086040|t=2017. The Chemistry Development Kit (CDK) v2 0: atom typing, depiction, molecular formulas, and substructure searching |pdf=|usr=}}{{29086040}} gab.com Text The Chemistry Development Kit (CDK) v2 0: atom typing, depiction, molecular formulas, and substructure searching JO: J Cheminform http://www.kidney.de/pget.php?&tw=1&pmid=29086040 #FOAvip Background: The Chemistry Development Kit (CDK) is a widely used open source cheminformatics toolkit, providing data structures to represent chemical concepts along with methods to manipulate such structures and perform computations on them. The library implements a wide variety of cheminformatics algorithms ranging from chemical structure canonicalization to molecular descriptor calculations and pharmacophore perception. It is used in drug discovery, metabolomics, and toxicology. Over the last 10 years, the code base has grown significantly, however, resulting in many complex interdependencies among components and poor performance of many algorithms. Results: We report improvements to the CDK v2.0 since the v1.2 release series, specifically addressing the increased functional complexity and poor performance. We first summarize the addition of new functionality, such atom typing and molecular formula handling, and improvement to existing functionality that has led to significantly better performance for substructure searching, molecular fingerprints, and rendering of molecules. Second, we outline how the CDK has evolved with respect to quality control and the approaches we have adopted to ensure stability, including a code review mechanism. Conclusions: This paper highlights our continued efforts to provide a community driven, open source cheminformatics library, and shows that such collaborative projects can thrive over extended periods of time, resulting in a high-quality and performant library. By taking advantage of community support and contributions, we show that an open source cheminformatics project can act as a peer reviewed publishing platform for scientific computing software.Graphical abstractCDK 2.0 provides new features and improved performance Electronic supplementary material: The online version of this article (doi:10.1186/s13321-017-0220-4) contains supplementary material, which is available to authorized users. Twit Text FOAVip The Chemistry Development Kit (CDK) v2 0: atom typing, depiction, molecular formulas, and substructure searching ????J Cheminform http://www.kidney.de/pget.php?&tw=1&pmid=29086040 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29086040 #FOAvip English Wikipedia <ref>{{Cite pmid|29086040}}</ref> The Chemistry Development Kit (CDK) v2 0: atom typing, depiction, molecular formulas, and substructure searching #MMPMID29086040 Willighagen EL; Mayfield JW; Alvarsson J; Berg A; Carlsson L; Jeliazkova N; Kuhn S; Pluskal T; Rojas-Chertó M; Spjuth O; Torrance G; Evelo CT; Guha R; Steinbeck C J Cheminform 2017[]; 9 (ä): ä PMID29086040show ga Background: The Chemistry Development Kit (CDK) is a widely used open source cheminformatics toolkit, providing data structures to represent chemical concepts along with methods to manipulate such structures and perform computations on them. The library implements a wide variety of cheminformatics algorithms ranging from chemical structure canonicalization to molecular descriptor calculations and pharmacophore perception. It is used in drug discovery, metabolomics, and toxicology. Over the last 10 years, the code base has grown significantly, however, resulting in many complex interdependencies among components and poor performance of many algorithms. Results: We report improvements to the CDK v2.0 since the v1.2 release series, specifically addressing the increased functional complexity and poor performance. We first summarize the addition of new functionality, such atom typing and molecular formula handling, and improvement to existing functionality that has led to significantly better performance for substructure searching, molecular fingerprints, and rendering of molecules. Second, we outline how the CDK has evolved with respect to quality control and the approaches we have adopted to ensure stability, including a code review mechanism. Conclusions: This paper highlights our continued efforts to provide a community driven, open source cheminformatics library, and shows that such collaborative projects can thrive over extended periods of time, resulting in a high-quality and performant library. By taking advantage of community support and contributions, we show that an open source cheminformatics project can act as a peer reviewed publishing platform for scientific computing software.Graphical abstractCDK 2.0 provides new features and improved performance Electronic supplementary material: The online version of this article (doi:10.1186/s13321-017-0220-4) contains supplementary material, which is available to authorized users. äThe Chemistry Development Kit (CDK) v2 0: atom typing, depiction, mole(epmc).pdf DeepDyve Pubget Overpricing