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10.7554/eLife.23382 http://scihub22266oqcxt.onion/10.7554/eLife.23382 C5461110!5461110 !28583252     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28583252 &cmd=llinks): Failed to open stream: HTTP request failed! 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Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth |pdf=|usr=}}{{28583252 }} gab.com Text Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=28583252 #FOAvip The gene desert upstream of the MYC oncogene on chromosome 8q24 contains susceptibility loci for several major forms of human cancer. The region shows high conservation between human and mouse and contains multiple MYC enhancers that are activated in tumor cells. However, the role of this region in normal development has not been addressed. Here we show that a 538 kb deletion of the entire MYC upstream super-enhancer region in mice results in 50% to 80% decrease in Myc expression in multiple tissues. The mice are viable and show no overt phenotype. However, they are resistant to tumorigenesis, and most normal cells isolated from them grow slowly in culture. These results reveal that only cells whose MYC activity is increased by serum or oncogenic driver mutations depend on the 8q24 super-enhancer region, and indicate that targeting the activity of this element is a promising strategy of cancer chemoprevention and therapy. Twit Text FOAVip Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=28583252 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28583252 #FOAvip English Wikipedia <ref>{{Cite pmid|28583252 }}</ref> Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth #MMPMID28583252 Dave K ; Sur I ; Yan J ; Zhang J ; Kaasinen E ; Zhong F ; Blaas L ; Li X ; Kharazi S ; Gustafsson C ; De Paepe A ; Månsson R ; Taipale J Elife 2017[Jun]; 6 (ä): ä PMID28583252 show ga The gene desert upstream of the MYC oncogene on chromosome 8q24 contains susceptibility loci for several major forms of human cancer. The region shows high conservation between human and mouse and contains multiple MYC enhancers that are activated in tumor cells. However, the role of this region in normal development has not been addressed. Here we show that a 538 kb deletion of the entire MYC upstream super-enhancer region in mice results in 50% to 80% decrease in Myc expression in multiple tissues. The mice are viable and show no overt phenotype. However, they are resistant to tumorigenesis, and most normal cells isolated from them grow slowly in culture. These results reveal that only cells whose MYC activity is increased by serum or oncogenic driver mutations depend on the 8q24 super-enhancer region, and indicate that targeting the activity of this element is a promising strategy of cancer chemoprevention and therapy. |*Enhancer Elements, Genetic [MESH] |*Sequence Deletion [MESH] |Animals [MESH] |Carcinogenesis [MESH] |Gene Expression [MESH] |Mice [MESH] |Mice, Knockout [MESH]Mice deficient of Myc super-enhancer region reveal differential contro(epmc).pdf DeepDyve Pubget Overpricing