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10.1111/imm.12715 http://scihub22266oqcxt.onion/10.1111/imm.12715 C5461105!5461105 !28108989     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28108989 &cmd=llinks): Failed to open stream: HTTP request failed! 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TIGIT signalling pathway negatively regulates CD4(+) T-cell responses in systemic lupus erythematosus |pdf=|usr=}}{{28108989 }} gab.com Text TIGIT signalling pathway negatively regulates CD4(+) T-cell responses in systemic lupus erythematosus JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=28108989 #FOAvip B-lymphocyte hyperactivity in systemic lupus erythematosus (SLE) is T-cell-dependent, and CD4(+) T-cell activation is essential to SLE pathogenesis. However, the mechanism of the deregulation of CD4(+) T cells in SLE is largely unknown. T-cell immunoglobulin and ITIM domain (TIGIT) is a new inhibitory receptor preferentially expressed on activated CD4(+) T cells. Here, we address the role of TIGIT in the pathogenesis of SLE. Our results showed that TIGIT expression on CD4(+) T cells was significantly elevated in patients with SLE and highly correlated with the activity of the disease. TIGIT(+) CD4(+) T cells from both healthy individuals and patients with SLE had a more activated phenotype than TIGIT(-) CD4(+) T cells. In contrast, the activation, proliferation and cytokine production potential of TIGIT(+) CD4(+) T cells were significantly lower than those of TIGIT(-) CD4(+) T cells. Furthermore, activation of the TIGIT pathway by using CD155 could substantially down-regulate the activities of CD4(+) T cells from SLE patients in vitro, and in vivo administration of CD155 resulted in a delayed development of SLE in MRL/lpr mice. TIGIT is a powerful negative regulator of CD4(+) T cells in SLE, which suggests that the TIGIT signalling pathway may be used as a potential therapeutic target for treating this disease. Twit Text FOAVip TIGIT signalling pathway negatively regulates CD4(+) T-cell responses in systemic lupus erythematosus ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=28108989 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28108989 #FOAvip English Wikipedia <ref>{{Cite pmid|28108989 }}</ref> TIGIT signalling pathway negatively regulates CD4(+) T-cell responses in systemic lupus erythematosus #MMPMID28108989 Mao L ; Hou H ; Wu S ; Zhou Y ; Wang J ; Yu J ; Wu X ; Lu Y ; Mao L ; Bosco MJ ; Wang F ; Sun Z Immunology 2017[Jul]; 151 (3 ): 280-290 PMID28108989 show ga B-lymphocyte hyperactivity in systemic lupus erythematosus (SLE) is T-cell-dependent, and CD4(+) T-cell activation is essential to SLE pathogenesis. However, the mechanism of the deregulation of CD4(+) T cells in SLE is largely unknown. T-cell immunoglobulin and ITIM domain (TIGIT) is a new inhibitory receptor preferentially expressed on activated CD4(+) T cells. Here, we address the role of TIGIT in the pathogenesis of SLE. Our results showed that TIGIT expression on CD4(+) T cells was significantly elevated in patients with SLE and highly correlated with the activity of the disease. TIGIT(+) CD4(+) T cells from both healthy individuals and patients with SLE had a more activated phenotype than TIGIT(-) CD4(+) T cells. In contrast, the activation, proliferation and cytokine production potential of TIGIT(+) CD4(+) T cells were significantly lower than those of TIGIT(-) CD4(+) T cells. Furthermore, activation of the TIGIT pathway by using CD155 could substantially down-regulate the activities of CD4(+) T cells from SLE patients in vitro, and in vivo administration of CD155 resulted in a delayed development of SLE in MRL/lpr mice. TIGIT is a powerful negative regulator of CD4(+) T cells in SLE, which suggests that the TIGIT signalling pathway may be used as a potential therapeutic target for treating this disease. |*Lymphocyte Activation [MESH] |*Signal Transduction [MESH] |Animals [MESH] |Biomarkers/metabolism [MESH] |CD4-Positive T-Lymphocytes/immunology/*metabolism [MESH] |Case-Control Studies [MESH] |Cell Proliferation [MESH] |Cells, Cultured [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Humans [MESH] |Lupus Erythematosus, Systemic/diagnosis/immunology/*metabolism/prevention & control [MESH] |Mice, Inbred MRL lpr [MESH] |Phenotype [MESH] |Receptors, Immunologic/immunology/*metabolism [MESH] |Receptors, Virus/administration & dosage [MESH] |Time Factors [MESH]TIGIT signalling pathway negatively regulates CD4(+) T-cell responses (epmc).pdf DeepDyve Pubget Overpricing