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2017 ; 151
(3
): 291-303
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English Wikipedia
CD4(+) CD25(+) GARP(+) regulatory T cells display a compromised suppressive
function in patients with dilated cardiomyopathy
#MMPMID28207945
Wei Y
; Yu K
; Wei H
; Su X
; Zhu R
; Shi H
; Sun H
; Luo Q
; Xu W
; Xiao J
; Zhong Y
; Zeng Q
Immunology
2017[Jul]; 151
(3
): 291-303
PMID28207945
show ga
Dilated cardiomyopathy (DCM) is a lethal inflammatory heart disease and closely
connected with dysfunction of the immune system. Glycoprotein A repetitions
predominant (GARP) expressed on activated CD4(+) T cells with suppressive
activity has been established. This study aimed to investigate the frequency and
function of circulating CD4(+) CD25(+) GARP(+) regulatory T (Treg) cells in
DCM. Forty-five DCM patients and 46 controls were enrolled in this study. There
was a significant increase in peripheral T helper type 1 (Th1) and Th17 number
and their related cytokines [interferon-? (IFN-?), interleukin (IL-17)], and an
obvious decrease in Treg number, transforming growth factor-?(1) (TGF-?(1) )
levels and the expression of forkhead box P3 (FOXP3) and GARP in patients with
DCM compared with controls. In addition, the suppressive function of CD4(+)
CD25(+) GARP(+) Treg cells was impaired in DCM patients upon T-cell receptor
stimulation detected using CFSE dye. Lower level of TGF-?(1) and higher levels of
IFN-? and IL-17 detected using ELISA were found in supernatants of the cultured
CD4(+) CD25(+) GARP(+) Treg cells in DCM patients compared with controls.
Together, our results indicate that CD4(+) CD25(+) GARP(+) Treg cells are
defective in DCM patients and GARP seems to be a better molecular definition of
the regulatory phenotype. Therefore, it might be an attractive stategy to pay
more attention to GARP in DCM patients.
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