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10.1084/jem.20160553 http://scihub22266oqcxt.onion/10.1084/jem.20160553 C5460991!5460991 !28487311     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28487311 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Exp+Med 2017 ; 214 (6 ): 1787-1808 Nephropedia Template TP {{tp|p=28487311 |t=2017. Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation |pdf=|usr=}}{{28487311 }} gab.com Text Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=28487311 #FOAvip Egr2 and 3 are important for maintaining immune homeostasis. Here we define a fundamental function of Egr2 and 3 operating as a checkpoint that controls the transition between clonal expansion and differentiation of effector T cells. Egr2 and 3 deficiency resulted in defective clonal expansion but hyperactivation and excessive differentiation of T cells in response to viral infection. Conversely, sustained Egr2 expression enhanced expansion but severely impaired effector differentiation. Egr2 bound to and controlled the expression of genes regulating proliferation (Myc and Myb) and differentiation repressors (Bcl6, Id3), while repressing transcription factors required for effector function (Zeb2, RORa, RORc, and Bhlhe40). Egr2 and 3 expression in T cells was regulated reciprocally by antigen and IFN?, providing a mechanism for adjusting proliferation and differentiation of individual T cells. Thus, Egr2 and 3 are upstream regulators of effector CD4 and CD8 T cells that are essential for optimal responses with limited immunopathology. Twit Text FOAVip Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=28487311 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28487311 #FOAvip English Wikipedia <ref>{{Cite pmid|28487311 }}</ref> Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation #MMPMID28487311 Miao T ; Symonds ALJ ; Singh R ; Symonds JD ; Ogbe A ; Omodho B ; Zhu B ; Li S ; Wang P J Exp Med 2017[Jun]; 214 (6 ): 1787-1808 PMID28487311 show ga Egr2 and 3 are important for maintaining immune homeostasis. Here we define a fundamental function of Egr2 and 3 operating as a checkpoint that controls the transition between clonal expansion and differentiation of effector T cells. Egr2 and 3 deficiency resulted in defective clonal expansion but hyperactivation and excessive differentiation of T cells in response to viral infection. Conversely, sustained Egr2 expression enhanced expansion but severely impaired effector differentiation. Egr2 bound to and controlled the expression of genes regulating proliferation (Myc and Myb) and differentiation repressors (Bcl6, Id3), while repressing transcription factors required for effector function (Zeb2, RORa, RORc, and Bhlhe40). Egr2 and 3 expression in T cells was regulated reciprocally by antigen and IFN?, providing a mechanism for adjusting proliferation and differentiation of individual T cells. Thus, Egr2 and 3 are upstream regulators of effector CD4 and CD8 T cells that are essential for optimal responses with limited immunopathology. |*Adaptive Immunity/genetics [MESH] |*Cell Differentiation/genetics [MESH] |Animals [MESH] |Antigens/metabolism [MESH] |Antiviral Agents/metabolism [MESH] |Cell Proliferation/genetics [MESH] |Clone Cells [MESH] |Early Growth Response Protein 2/*metabolism [MESH] |Early Growth Response Protein 3/*metabolism [MESH] |Gene Expression Profiling [MESH] |Gene Expression Regulation [MESH] |Interferon-gamma/metabolism [MESH] |Lymphocyte Activation/genetics [MESH] |Mice, Inbred C57BL [MESH] |Protein Binding/genetics [MESH] |Receptors, Antigen, T-Cell/metabolism [MESH] |Signal Transduction/genetics [MESH] |T-Lymphocytes/*cytology/immunology/virology [MESH] |Time Factors [MESH]Egr2 and 3 control adaptive immune responses by temporally uncoupling (epmc).pdf DeepDyve Pubget Overpricing