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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Endocr+Rev 2017 ; 38 (2): 145-68 Nephropedia Template TP
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Emerging Roles for MicroRNAs in Diabetic Microvascular Disease: Novel Targets for Therapy #MMPMID28323921
Zhang Y; Sun X; Icli B; Feinberg MW
Endocr Rev 2017[Apr]; 38 (2): 145-68 PMID28323921show ga
Impaired microvascular function is a hallmark during the development of insulin resistance and in diabetic subjectsMicroRNAs, small noncoding RNAs that fine-tune gene expression, have emerged as critical regulators in insulin-responsive tissues and cell types important for maintaining vascular homeostasis and preventing the sequelae of diabetes-induced end organ injuryCurrent pathophysiological paradigms of microRNAs and their target genes demonstrate novel mechanisms and therapeutic targets in regulating the diabetic microvasculature in diabetes-associated complications such as retinopathy, nephropathy, wound healing, and myocardial injuryCirculating microRNAs in exosomes or microvesicles may be diagnostically useful in type I or type II diabetesEmerging delivery platforms for manipulating microRNA expression or function may serve as the next frontier in therapeutic intervention to improve diabetes-associated microvascular dysfunction and its attendant clinical consequences