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10.1210/er.2016-1122

http://scihub22266oqcxt.onion/10.1210/er.2016-1122
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C5460677!5460677!28323921
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suck abstract from ncbi


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pmid28323921      Endocr+Rev 2017 ; 38 (2): 145-68
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  • Emerging Roles for MicroRNAs in Diabetic Microvascular Disease: Novel Targets for Therapy #MMPMID28323921
  • Zhang Y; Sun X; Icli B; Feinberg MW
  • Endocr Rev 2017[Apr]; 38 (2): 145-68 PMID28323921show ga
  • Impaired microvascular function is a hallmark during the development of insulin resistance and in diabetic subjectsMicroRNAs, small noncoding RNAs that fine-tune gene expression, have emerged as critical regulators in insulin-responsive tissues and cell types important for maintaining vascular homeostasis and preventing the sequelae of diabetes-induced end organ injuryCurrent pathophysiological paradigms of microRNAs and their target genes demonstrate novel mechanisms and therapeutic targets in regulating the diabetic microvasculature in diabetes-associated complications such as retinopathy, nephropathy, wound healing, and myocardial injuryCirculating microRNAs in exosomes or microvesicles may be diagnostically useful in type I or type II diabetesEmerging delivery platforms for manipulating microRNA expression or function may serve as the next frontier in therapeutic intervention to improve diabetes-associated microvascular dysfunction and its attendant clinical consequences
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