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10.1186/s12882-017-0588-4

http://scihub22266oqcxt.onion/10.1186/s12882-017-0588-4
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suck abstract from ncbi


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pmid28583107      BMC+Nephrol 2017 ; 18 (ä): ä
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  • The impact of peritoneal dialysis-related peritonitis on mortality in peritoneal dialysis patients #MMPMID28583107
  • Ye H; Zhou Q; Fan L; Guo Q; Mao H; Huang F; Yu X; Yang X
  • BMC Nephrol 2017[]; 18 (ä): ä PMID28583107show ga
  • Background: Results concerning the association between peritoneal dialysis-related peritonitis and mortality in peritoneal dialysis patients are inconclusive, with one potential reason being that the time-dependent effect of peritonitis has rarely been considered in previous studies. This study aimed to evaluate whether peritonitis has a negative impact on mortality in a large cohort of peritoneal dialysis patients. We also assessed the changing impact of peritonitis on patient mortality with respect to duration of follow-up. Methods: This retrospective cohort study included incident patients who started peritoneal dialysis from 1 January 2006 to 31 December 2011. Episodes of peritonitis were recorded at the time of onset, and peritonitis was parameterized as a time-dependent variable for analysis. We used the Cox regression model to assess whether peritonitis has a negative impact on mortality. Results: A total of 1321 patients were included. The mean age was 48.1 ± 15.3 years, 41.3% were female, and 23.5% with diabetes mellitus. The median (interquartile) follow-up time was 34 (21?48) months. After adjusting for confounders, peritonitis was independently associated with 95% increased risk of all-cause mortality (hazard ratio, 1.95; 95% confidence interval: 1.46?2.60), 90% increased risk of cardiovascular mortality (hazard ratio, 1.90; 95% confidence interval: 1.28?2.81) and near 4-fold increased risk of infection-related mortality (hazard ratio, 4.94; 95% confidence interval: 2.47?9.86). Further analyses showed that peritonitis was not significantly associated with mortality within 2 years of peritoneal dialysis initiation, but strongly influenced mortality in patients dialysed longer than 2 years. Conclusions: Peritonitis was independently associated with higher risk of all-cause, cardiovascular and infection-related mortality in peritoneal dialysis patients, and its impact on mortality was more significant in patients with longer peritoneal dialysis duration. Electronic supplementary material: The online version of this article (doi:10.1186/s12882-017-0588-4) contains supplementary material, which is available to authorized users.
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