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10.1038/s41598-017-02444-2 http://scihub22266oqcxt.onion/10.1038/s41598-017-02444-2 C5460286!5460286 !28588299     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28588299 &cmd=llinks): Failed to open stream: HTTP request failed! 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Protective effect of rosiglitazone on kidney function in high-fat challenged human-CRP transgenic mice: a possible role for adiponectin and miR-21? |pdf=|usr=}}{{28588299 }} gab.com Text Protective effect of rosiglitazone on kidney function in high-fat challenged human-CRP transgenic mice: a possible role for adiponectin and miR-21 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28588299 #FOAvip Obesity-related albuminuria is associated with decline of kidney function and is considered a first sign of diabetic nephropathy. Suggested factors linking obesity to kidney dysfunction include low-grade inflammation, insulin resistance and adipokine dysregulation. Here, we investigated the effects of two pharmacological compounds with established anti-inflammatory properties, rosiglitazone and rosuvastatin, on kidney dysfunction during high-fat diet (HFD)-induced obesity. For this, human CRP transgenic mice were fed standard chow, a lard-based HFD, HFD+rosuvastatin or HFD+rosiglitazone for 42 weeks to study effects on insulin resistance; plasma inflammatory markers and adipokines; and renal pathology. Rosiglitazone but not rosuvastatin prevented HFD-induced albuminuria and renal fibrosis and inflammation. Also, rosiglitazone prevented HFD-induced KIM-1 expression, while levels were doubled with rosuvastatin. This was mirrored by miR-21 expression, which plays a role in fibrosis and is associated with renal dysfunction. Plasma insulin did not correlate with albuminuria. Only rosiglitazone increased circulating adiponectin concentrations. In all, HFD-induced albuminuria, and renal inflammation, injury and fibrosis is prevented by rosiglitazone but not by rosuvastatin. These beneficial effects of rosiglitazone are linked to lowered miR-21 expression but not connected with the selectively enhanced plasma adiponectin levels observed in rosiglitazone-treated animals. Twit Text FOAVip Protective effect of rosiglitazone on kidney function in high-fat challenged human-CRP transgenic mice: a possible role for adiponectin and miR-21 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28588299 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28588299 #FOAvip English Wikipedia <ref>{{Cite pmid|28588299 }}</ref> Protective effect of rosiglitazone on kidney function in high-fat challenged human-CRP transgenic mice: a possible role for adiponectin and miR-21? #MMPMID28588299 Morrison MC ; Yakala GK ; Liang W ; Wielinga PY ; Salic K ; van Koppen A ; Tomar T ; Kleemann R ; Heeringa P ; Kooistra T Sci Rep 2017[Jun]; 7 (1 ): 2915 PMID28588299 show ga Obesity-related albuminuria is associated with decline of kidney function and is considered a first sign of diabetic nephropathy. Suggested factors linking obesity to kidney dysfunction include low-grade inflammation, insulin resistance and adipokine dysregulation. Here, we investigated the effects of two pharmacological compounds with established anti-inflammatory properties, rosiglitazone and rosuvastatin, on kidney dysfunction during high-fat diet (HFD)-induced obesity. For this, human CRP transgenic mice were fed standard chow, a lard-based HFD, HFD+rosuvastatin or HFD+rosiglitazone for 42 weeks to study effects on insulin resistance; plasma inflammatory markers and adipokines; and renal pathology. Rosiglitazone but not rosuvastatin prevented HFD-induced albuminuria and renal fibrosis and inflammation. Also, rosiglitazone prevented HFD-induced KIM-1 expression, while levels were doubled with rosuvastatin. This was mirrored by miR-21 expression, which plays a role in fibrosis and is associated with renal dysfunction. Plasma insulin did not correlate with albuminuria. Only rosiglitazone increased circulating adiponectin concentrations. In all, HFD-induced albuminuria, and renal inflammation, injury and fibrosis is prevented by rosiglitazone but not by rosuvastatin. These beneficial effects of rosiglitazone are linked to lowered miR-21 expression but not connected with the selectively enhanced plasma adiponectin levels observed in rosiglitazone-treated animals. |Adipokines/blood [MESH] |Adiponectin/genetics/metabolism [MESH] |Animals [MESH] |Biomarkers [MESH] |Blood Glucose [MESH] |C-Reactive Protein/*genetics [MESH] |Diet, High-Fat [MESH] |Fibrosis [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Inflammation Mediators/metabolism [MESH] |Insulin/blood [MESH] |Kidney/*drug effects/*metabolism/pathology [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |MicroRNAs/genetics [MESH] |Protective Agents/*pharmacology [MESH]Protective effect of rosiglitazone on kidney function in high-fat chal(epmc).pdf DeepDyve Pubget Overpricing