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10.1038/ncomms15637 http://scihub22266oqcxt.onion/10.1038/ncomms15637 C5460038!5460038 !28561066     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28561066 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (ä): 15637 Nephropedia Template TP {{tp|p=28561066 |t=2017. WIPI3 and WIPI4 ?-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy |pdf=|usr=}}{{28561066 }} gab.com Text WIPI3 and WIPI4 -propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28561066 #FOAvip Autophagy is controlled by AMPK and mTOR, both of which associate with ULK1 and control the production of phosphatidylinositol 3-phosphate (PtdIns3P), a prerequisite for autophagosome formation. Here we report that WIPI3 and WIPI4 scaffold the signal control of autophagy upstream of PtdIns3P production and have a role in the PtdIns3P effector function of WIPI1-WIPI2 at nascent autophagosomes. In response to LKB1-mediated AMPK stimulation, WIPI4-ATG2 is released from a WIPI4-ATG2/AMPK-ULK1 complex and translocates to nascent autophagosomes, controlling their size, to which WIPI3, in complex with FIP200, also contributes. Upstream, WIPI3 associates with AMPK-activated TSC complex at lysosomes, regulating mTOR. Our WIPI interactome analysis reveals the scaffold functions of WIPI proteins interconnecting autophagy signal control and autophagosome formation. Our functional kinase screen uncovers a novel regulatory link between LKB1-mediated AMPK stimulation that produces a direct signal via WIPI4, and we show that the AMPK-related kinases NUAK2 and BRSK2 regulate autophagy through WIPI4. Twit Text FOAVip WIPI3 and WIPI4 -propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28561066 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28561066 #FOAvip English Wikipedia <ref>{{Cite pmid|28561066 }}</ref> WIPI3 and WIPI4 ?-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy #MMPMID28561066 Bakula D ; Müller AJ ; Zuleger T ; Takacs Z ; Franz-Wachtel M ; Thost AK ; Brigger D ; Tschan MP ; Frickey T ; Robenek H ; Macek B ; Proikas-Cezanne T Nat Commun 2017[May]; 8 (ä): 15637 PMID28561066 show ga Autophagy is controlled by AMPK and mTOR, both of which associate with ULK1 and control the production of phosphatidylinositol 3-phosphate (PtdIns3P), a prerequisite for autophagosome formation. Here we report that WIPI3 and WIPI4 scaffold the signal control of autophagy upstream of PtdIns3P production and have a role in the PtdIns3P effector function of WIPI1-WIPI2 at nascent autophagosomes. In response to LKB1-mediated AMPK stimulation, WIPI4-ATG2 is released from a WIPI4-ATG2/AMPK-ULK1 complex and translocates to nascent autophagosomes, controlling their size, to which WIPI3, in complex with FIP200, also contributes. Upstream, WIPI3 associates with AMPK-activated TSC complex at lysosomes, regulating mTOR. Our WIPI interactome analysis reveals the scaffold functions of WIPI proteins interconnecting autophagy signal control and autophagosome formation. Our functional kinase screen uncovers a novel regulatory link between LKB1-mediated AMPK stimulation that produces a direct signal via WIPI4, and we show that the AMPK-related kinases NUAK2 and BRSK2 regulate autophagy through WIPI4. |*Autophagy [MESH] |*Signal Transduction [MESH] |AMP-Activated Protein Kinase Kinases [MESH] |AMP-Activated Protein Kinases/chemistry [MESH] |Adaptor Proteins, Signal Transducing/metabolism [MESH] |Autophagy-Related Protein-1 Homolog/chemistry [MESH] |Autophagy-Related Proteins/chemistry [MESH] |Carrier Proteins/*chemistry [MESH] |Cell Line, Tumor [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Intracellular Signaling Peptides and Proteins/chemistry [MESH] |Lysosomes/metabolism [MESH] |Phagosomes/metabolism [MESH] |Phosphatidylinositol Phosphates/chemistry [MESH] |Protein Binding [MESH] |Protein Conformation [MESH] |Protein Serine-Threonine Kinases/*chemistry [MESH]WIPI3 and WIPI4 ?-propellers are scaffolds for LKB1-AMPK-TSC signallin(epmc).pdf DeepDyve Pubget Overpricing