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Clinical features and prognostic factors of adult secondary hemophagocytic
syndrome: Analysis of 47 cases
#MMPMID28562543
Guo Y
; Bai Y
; Gu L
Medicine (Baltimore)
2017[Jun]; 96
(22
): e6935
PMID28562543
show ga
This study aimed to investigate the relationship between clinical features and
prognosis of adult secondary hemophagocytic syndrome (HPS).A retrospective
analysis was conducted on the pathogenesis, clinical manifestations, laboratory
examinations, treatment options, and prognosis of 47 patients with adult
secondary HPS diagnosed from January 2013 to December 2015.The average age at
disease onset was (46.26?±?18.98) years with a male:female ratio of 1:1.14.
Thirteen patients died, with the highest mortality rate in patients with HPS
underlying blood system malignancy (33.33%, 2/6). The mortality rate in patients
with HPS underlying autoimmune disorders was the lowest (18.75%, 3/16). The
Kaplan-Meier analysis indicated that signs of hemorrhage, pulmonary and nervous
system involvement, serous effusion, and decrease in the blood platelet count
were associated with death. The Cox regression analysis revealed that signs of
hemorrhage, pulmonary involvement, serous effusion, and nervous system
involvement were independent risk factors of patient death.Adult secondary HPS
has multiple etiologies and diversified clinical features. The risk of death
increases in patients with signs of hemorrhage, serous effusion, pulmonary
involvement, and nervous system involvement.
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