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10.7554/eLife.24476 http://scihub22266oqcxt.onion/10.7554/eLife.24476 C5459576!5459576!28518056     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28518056|t=2017. Functionally diverse human T cells recognize non-microbial antigens presented by MR1 |pdf=|usr=}}{{28518056}} gab.com Text Functionally diverse human T cells recognize non-microbial antigens presented by MR1 JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=28518056 #FOAvip MHC class I-related molecule MR1 presents riboflavin- and folate-related metabolites to mucosal-associated invariant T cells, but it is unknown whether MR1 can present alternative antigens to other T cell lineages. In healthy individuals we identified MR1-restricted T cells (named MR1T cells) displaying diverse TCRs and reacting to MR1-expressing cells in the absence of microbial ligands. Analysis of MR1T cell clones revealed specificity for distinct cell-derived antigens and alternative transcriptional strategies for metabolic programming, cell cycle control and functional polarization following antigen stimulation. Phenotypic and functional characterization of MR1T cell clones showed multiple chemokine receptor expression profiles and secretion of diverse effector molecules, suggesting functional heterogeneity. Accordingly, MR1T cells exhibited distinct T helper-like capacities upon MR1-dependent recognition of target cells expressing physiological levels of surface MR1. These data extend the role of MR1 beyond microbial antigen presentation and indicate MR1T cells are a normal part of the human T cell repertoire.DOI:http://dx.doi.org/10.7554/eLife.24476.001 Twit Text FOAVip Functionally diverse human T cells recognize non-microbial antigens presented by MR1 ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=28518056 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28518056 #FOAvip English Wikipedia <ref>{{Cite pmid|28518056}}</ref> Functionally diverse human T cells recognize non-microbial antigens presented by MR1 #MMPMID28518056 Lepore M; Kalinichenko A; Calogero S; Kumar P; Paleja B; Schmaler M; Narang V; Zolezzi F; Poidinger M; Mori L; De Libero G eLife 2017[]; 6 (ä): ä PMID28518056show ga MHC class I-related molecule MR1 presents riboflavin- and folate-related metabolites to mucosal-associated invariant T cells, but it is unknown whether MR1 can present alternative antigens to other T cell lineages. In healthy individuals we identified MR1-restricted T cells (named MR1T cells) displaying diverse TCRs and reacting to MR1-expressing cells in the absence of microbial ligands. Analysis of MR1T cell clones revealed specificity for distinct cell-derived antigens and alternative transcriptional strategies for metabolic programming, cell cycle control and functional polarization following antigen stimulation. Phenotypic and functional characterization of MR1T cell clones showed multiple chemokine receptor expression profiles and secretion of diverse effector molecules, suggesting functional heterogeneity. Accordingly, MR1T cells exhibited distinct T helper-like capacities upon MR1-dependent recognition of target cells expressing physiological levels of surface MR1. These data extend the role of MR1 beyond microbial antigen presentation and indicate MR1T cells are a normal part of the human T cell repertoire.DOI:http://dx.doi.org/10.7554/eLife.24476.001 äFunctionally diverse human T cells recognize non-microbial antigens pr(epmc).pdf DeepDyve Pubget Overpricing