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10.7554/eLife.27311 http://scihub22266oqcxt.onion/10.7554/eLife.27311 C5459573!5459573!28527239     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28527239|t=2017. The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition |pdf=|usr=}}{{28527239}} gab.com Text The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=28527239 #FOAvip Antibodies are critical components of the human adaptive immune system, providing versatile scaffolds to display diverse antigen-binding surfaces. Nevertheless, most antibodies have similar architectures, with the variable immunoglobulin domains of the heavy and light chain each providing three hypervariable loops, which are varied to generate diversity. The recent identification of a novel class of antibody in humans from malaria endemic regions of Africa was therefore surprising as one hypervariable loop contains the entire collagen-binding domain of human LAIR1. Here, we present the structure of the Fab fragment of such an antibody. We show that its antigen-binding site has adopted an architecture that positions LAIR1, while itself being occluded. This therefore represents a novel means of antigen recognition, in which the Fab fragment of an antibody acts as an adaptor, linking a human protein insert with antigen-binding potential to the constant antibody regions which mediate immune cell recruitment.DOI:http://dx.doi.org/10.7554/eLife.27311.001 Twit Text FOAVip The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=28527239 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28527239 #FOAvip English Wikipedia <ref>{{Cite pmid|28527239}}</ref> The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition #MMPMID28527239 Hsieh FL; Higgins MK eLife 2017[]; 6 (ä): ä PMID28527239show ga Antibodies are critical components of the human adaptive immune system, providing versatile scaffolds to display diverse antigen-binding surfaces. Nevertheless, most antibodies have similar architectures, with the variable immunoglobulin domains of the heavy and light chain each providing three hypervariable loops, which are varied to generate diversity. The recent identification of a novel class of antibody in humans from malaria endemic regions of Africa was therefore surprising as one hypervariable loop contains the entire collagen-binding domain of human LAIR1. Here, we present the structure of the Fab fragment of such an antibody. We show that its antigen-binding site has adopted an architecture that positions LAIR1, while itself being occluded. This therefore represents a novel means of antigen recognition, in which the Fab fragment of an antibody acts as an adaptor, linking a human protein insert with antigen-binding potential to the constant antibody regions which mediate immune cell recruitment.DOI:http://dx.doi.org/10.7554/eLife.27311.001 äThe structure of a LAIR1-containing human antibody reveals a novel mec(epmc).pdf DeepDyve Pubget Overpricing