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10.1007/s00018-016-2303-1 http://scihub22266oqcxt.onion/10.1007/s00018-016-2303-1 C5459373!5459373!27392607     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Life+Sci 2016 ; 73 (23): 4493-515 Nephropedia Template TP {{tp|p=27392607|t=2016. Epigenetic Regulation of Epithelia-Mesenchymal Transition |pdf=|usr=}}{{27392607}} gab.com Text Epigenetic Regulation of Epithelia-Mesenchymal Transition JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=27392607 #FOAvip Epithelial-mesenchymal transition (EMT) is an essential process for morphogenesis and organ development which reversibly enables polarized epithelial cells to lose their epithelial characteristics and acquire mesenchymal properties. It is now evident that the aberrant activation of EMT is also a critical mechanism to endow epithelial cancer cells with migratory and invasive capabilities associated with metastatic competence. This dedifferentiation program is mediated by a small cohort of pleiotropic transcription factors which in turn orchestrate a complex array of epigenetic mechanisms for the widespread changes in gene expression. Here, we review major epigenetic mechanisms with emphasis on histone modifications and discuss their implications in EMT and tumor progression. We also highlight mechanisms underlying transcription regulation concerted by various chromatin modifying proteins and EMT-inducing transcription factors at different molecular layers. Owing to the reversible nature of epigenetic modifications, a thorough understanding of their functions in EMT will not only provide new insights into our knowledge of cancer progression and metastasis, but also facilitates the development of diagnostic and therapeutic strategies for human malignancy. Twit Text FOAVip Epigenetic Regulation of Epithelia-Mesenchymal Transition ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=27392607 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27392607 #FOAvip English Wikipedia <ref>{{Cite pmid|27392607}}</ref> Epigenetic Regulation of Epithelia-Mesenchymal Transition #MMPMID27392607 Sun L; Fang J Cell Mol Life Sci 2016[Dec]; 73 (23): 4493-515 PMID27392607show ga Epithelial-mesenchymal transition (EMT) is an essential process for morphogenesis and organ development which reversibly enables polarized epithelial cells to lose their epithelial characteristics and acquire mesenchymal properties. It is now evident that the aberrant activation of EMT is also a critical mechanism to endow epithelial cancer cells with migratory and invasive capabilities associated with metastatic competence. This dedifferentiation program is mediated by a small cohort of pleiotropic transcription factors which in turn orchestrate a complex array of epigenetic mechanisms for the widespread changes in gene expression. Here, we review major epigenetic mechanisms with emphasis on histone modifications and discuss their implications in EMT and tumor progression. We also highlight mechanisms underlying transcription regulation concerted by various chromatin modifying proteins and EMT-inducing transcription factors at different molecular layers. Owing to the reversible nature of epigenetic modifications, a thorough understanding of their functions in EMT will not only provide new insights into our knowledge of cancer progression and metastasis, but also facilitates the development of diagnostic and therapeutic strategies for human malignancy. äEpigenetic Regulation of Epithelia-Mesenchymal Transition (epmc).pdf DeepDyve Pubget Overpricing