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10.12659/AJCR.902187

http://scihub22266oqcxt.onion/10.12659/AJCR.902187
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C5459220!5459220!28552902
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suck abstract from ncbi


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pmid28552902      Am+J+Case+Rep 2017 ; 18 (ä): 593-8
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  • IgG4-Related Disease Manifesting as Interstitial Nephritis Accompanied by Hypophysitis #MMPMID28552902
  • Matsuda K; Saito A; Takeuchi Y; Fukami H; Sato H; Nagasawa T
  • Am J Case Rep 2017[]; 18 (ä): 593-8 PMID28552902show ga
  • Patient: Male, 85Final Diagnosis: IgG4-related diseaseSymptoms: Renal failureMedication: ?Clinical Procedure: ?Specialty: NephrologyObjective:: Rare disease Background:: IgG4-related disease is a systemic disease with marked infiltration of IgG4-positive plasma cells into affected organs and elevated serum IgG4. On clinical examination, swelling, nodules, and hypertrophic lesions might appear simultaneously or metachronously in different organs. Case Report:: An 85-year-old man with sudden-onset polydipsia and polyuria insipidus was transported to our hospital because of hypothermia and general malaise. Laboratory tests revealed renal failure and central diabetes insipidus. According to his serum IgG4 level, the patient was diagnosed with possible IgG4-related kidney disease accompanied by IgG4-related hypophysitis. Abdominal contrast-enhanced computed tomography, hypophysis magnetic resonance imaging, and histological examination of the kidney were performed. Glucocorticoid therapy was administered and his renal function improved gradually. However, his central diabetes insipidus did not improve. Conclusions:: Glucocorticoid therapy showed different therapeutic effects on the kidney and posterior lobe of the hypophysis. It is possible that glucocorticoid therapy needs to be supported by other immunomodulatory therapies to have an effect on all affected organs.
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