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10.1038/nchembio.2297 http://scihub22266oqcxt.onion/10.1038/nchembio.2297 C5458775!5458775!28192414     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Chem+Biol 2017 ; 13 (4): 415-24 Nephropedia Template TP {{tp|p=28192414|t=2017. Selective in vivo metabolic cell-labeling-mediated cancer targeting |pdf=|usr=}}{{28192414}} gab.com Text Selective in vivo metabolic cell-labeling-mediated cancer targeting JO: Nat Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=28192414 #FOAvip Distinguishing cancer cells from normal cells through surface receptors is vital for cancer diagnosis and targeted therapy. Metabolic glycoengineering of unnatural sugars provides a powerful tool to manually introduce chemical receptors onto the cell surface; however, cancer-selective labeling still remains a great challenge. Herein we report the design of sugars that can selectively label cancer cells both in vitro and in vivo. Specifically, we inhibit the cell-labeling activity of tetraacetyl-N-azidoacetylmannosamine (Ac4ManAz) by converting its anomeric acetyl group to a caged ether bond that can be selectively cleaved by cancer-overexpressed enzymes and thus enables the overexpression of azido groups on the surface of cancer cells. Histone deacetylase and cathepsin L-responsive acetylated azidomannosamine, one such enzymatically activatable Ac4ManAz analog developed, mediated cancer-selective labeling in vivo, which enhanced tumor accumulation of a dibenzocyclooctyne?doxorubicin conjugate via click chemistry and enabled targeted therapy against LS174T colon cancer, MDA-MB-231 triple-negative breast cancer and 4T1 metastatic breast cancer in mice. Twit Text FOAVip Selective in vivo metabolic cell-labeling-mediated cancer targeting ????Nat Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=28192414 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28192414 #FOAvip English Wikipedia <ref>{{Cite pmid|28192414}}</ref> Selective in vivo metabolic cell-labeling-mediated cancer targeting #MMPMID28192414 Wang H; Wang R; Cai K; He H; Liu Y; Yen J; Wang Z; Xu M; Sun Y; Zhou X; Yin Q; Tang L; Dobrucki IT; Dobrucki LW; Chaney EJ; Boppart SA; Fan TM; Lezmi S; Chen X; Yin L; Cheng J Nat Chem Biol 2017[Apr]; 13 (4): 415-24 PMID28192414show ga Distinguishing cancer cells from normal cells through surface receptors is vital for cancer diagnosis and targeted therapy. Metabolic glycoengineering of unnatural sugars provides a powerful tool to manually introduce chemical receptors onto the cell surface; however, cancer-selective labeling still remains a great challenge. Herein we report the design of sugars that can selectively label cancer cells both in vitro and in vivo. Specifically, we inhibit the cell-labeling activity of tetraacetyl-N-azidoacetylmannosamine (Ac4ManAz) by converting its anomeric acetyl group to a caged ether bond that can be selectively cleaved by cancer-overexpressed enzymes and thus enables the overexpression of azido groups on the surface of cancer cells. Histone deacetylase and cathepsin L-responsive acetylated azidomannosamine, one such enzymatically activatable Ac4ManAz analog developed, mediated cancer-selective labeling in vivo, which enhanced tumor accumulation of a dibenzocyclooctyne?doxorubicin conjugate via click chemistry and enabled targeted therapy against LS174T colon cancer, MDA-MB-231 triple-negative breast cancer and 4T1 metastatic breast cancer in mice. äSelective in vivo metabolic cell-labeling-mediated cancer targeting (epmc).pdf DeepDyve Pubget Overpricing