Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1002/psc.2879 http://scihub22266oqcxt.onion/10.1002/psc.2879 C5458744!5458744 !27114096     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27114096 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Pept+Sci 2016 ; 22 (5 ): 368-73 Nephropedia Template TP {{tp|p=27114096 |t=2016. Peptide backbone modification in the bend region of amyloid-? inhibits fibrillogenesis but not oligomer formation |pdf=|usr=}}{{27114096 }} gab.com Text Peptide backbone modification in the bend region of amyloid- inhibits fibrillogenesis but not oligomer formation JO: J Pept Sci http://www.kidney.de/pget.php?&tw=1&pmid=27114096 #FOAvip Current evidence suggests that oligomers of the amyloid-? (A?) peptide are involved in the cellular toxicity of Alzheimer's disease, yet their biophysical characterization remains difficult because of lack of experimental control over the aggregation process under relevant physiologic conditions. Here, we show that modification of the A? peptide backbone at Gly29 allows for the formation of oligomers but inhibits fibril formation at physiologic temperature and pH. Our results suggest that the putative bend region in A? is important for higher-order aggregate formation. Copyright © 2016 European Peptide Society and John Wiley & Sons, Ltd. Twit Text FOAVip Peptide backbone modification in the bend region of amyloid- inhibits fibrillogenesis but not oligomer formation ????J Pept Sci http://www.kidney.de/pget.php?&tw=1&pmid=27114096 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27114096 #FOAvip English Wikipedia <ref>{{Cite pmid|27114096 }}</ref> Peptide backbone modification in the bend region of amyloid-? inhibits fibrillogenesis but not oligomer formation #MMPMID27114096 Johnson EC ; Lanning JD ; Meredith SC J Pept Sci 2016[May]; 22 (5 ): 368-73 PMID27114096 show ga Current evidence suggests that oligomers of the amyloid-? (A?) peptide are involved in the cellular toxicity of Alzheimer's disease, yet their biophysical characterization remains difficult because of lack of experimental control over the aggregation process under relevant physiologic conditions. Here, we show that modification of the A? peptide backbone at Gly29 allows for the formation of oligomers but inhibits fibril formation at physiologic temperature and pH. Our results suggest that the putative bend region in A? is important for higher-order aggregate formation. Copyright © 2016 European Peptide Society and John Wiley & Sons, Ltd. |Amino Acid Sequence [MESH] |Amyloid beta-Peptides/*chemistry/*genetics [MESH] |Amyloid/*chemistry [MESH] |Glycine/metabolism [MESH] |Hydrogen-Ion Concentration [MESH] |Models, Molecular [MESH] |Mutation [MESH] |Peptide Fragments/*chemical synthesis/chemistry [MESH]Peptide backbone modification in the bend region of amyloid-? inhibits(epmc).pdf DeepDyve Pubget Overpricing