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10.1016/j.eururo.2010.12.038 http://scihub22266oqcxt.onion/10.1016/j.eururo.2010.12.038 C5458734!5458734!21269758     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+Urol 2011 ; 59 (5): 734-44 Nephropedia Template TP {{tp|p=21269758|t=2011. Anoikis Disruption of Focal Adhesion-Akt Signaling Impairs Renal Cell Carcinoma |pdf=|usr=}}{{21269758}} gab.com Text Anoikis Disruption of Focal Adhesion-Akt Signaling Impairs Renal Cell Carcinoma JO: Eur Urol http://www.kidney.de/pget.php?&tw=1&pmid=21269758 #FOAvip Background: Quinazoline-based ?1-adrenoceptor antagonists suppress tumor growth by inducing apoptosis via an ?1-adrenoceptor-independent action. Anoikis is a unique mode of apoptosis consequential to insufficient cell-matrix interactions. Objective: This study investigated the apoptotic effect of novel quinazoline-based compounds on human renal cancer cells. Design, setting, and participants: Two cell lines were used: renal cell carcinoma (RCC) 786-0, harboring a von Hippel-Lindau (VHL) tumor-suppressor gene mutation with a highly angiogenic phenotype, and Caki cells (no VHL mutation). Measurements: The lead compound DZ-50 (10 ?M) led to significant inhibition of tumor-cell adhesion, migration, and invasion at a lower dose than doxazosin (25 ?M) in both RCC lines. Results and limitations: Doxazosin induced death-receptor-mediated apoptosis, while DZ-50 led to anoikis via targeting of the focal adhesion complex and AKT signaling that subsequently increased RCC susceptibility to caspase-8-mediated apoptosis. Both quinazoline compounds, doxazosin and DZ-50, significantly reduced RCC metastatic potential in vivo. Conclusions: Quinazoline-based drugs trigger anoikis in RCC by targeting the focal adhesion survival signaling. This potent antitumor action against human RCC suggests a novel quinazoline-based therapy targeting renal cancer. Twit Text FOAVip Anoikis Disruption of Focal Adhesion-Akt Signaling Impairs Renal Cell Carcinoma ????Eur Urol http://www.kidney.de/pget.php?&tw=1&pmid=21269758 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21269758 #FOAvip English Wikipedia <ref>{{Cite pmid|21269758}}</ref> Anoikis Disruption of Focal Adhesion-Akt Signaling Impairs Renal Cell Carcinoma #MMPMID21269758 Sakamoto S; Schwarze S; Kyprianou N Eur Urol 2011[May]; 59 (5): 734-44 PMID21269758show ga Background: Quinazoline-based ?1-adrenoceptor antagonists suppress tumor growth by inducing apoptosis via an ?1-adrenoceptor-independent action. Anoikis is a unique mode of apoptosis consequential to insufficient cell-matrix interactions. Objective: This study investigated the apoptotic effect of novel quinazoline-based compounds on human renal cancer cells. Design, setting, and participants: Two cell lines were used: renal cell carcinoma (RCC) 786-0, harboring a von Hippel-Lindau (VHL) tumor-suppressor gene mutation with a highly angiogenic phenotype, and Caki cells (no VHL mutation). Measurements: The lead compound DZ-50 (10 ?M) led to significant inhibition of tumor-cell adhesion, migration, and invasion at a lower dose than doxazosin (25 ?M) in both RCC lines. Results and limitations: Doxazosin induced death-receptor-mediated apoptosis, while DZ-50 led to anoikis via targeting of the focal adhesion complex and AKT signaling that subsequently increased RCC susceptibility to caspase-8-mediated apoptosis. Both quinazoline compounds, doxazosin and DZ-50, significantly reduced RCC metastatic potential in vivo. Conclusions: Quinazoline-based drugs trigger anoikis in RCC by targeting the focal adhesion survival signaling. This potent antitumor action against human RCC suggests a novel quinazoline-based therapy targeting renal cancer. äAnoikis Disruption of Focal Adhesion-Akt Signaling Impairs Renal Cell (epmc).pdf DeepDyve Pubget Overpricing