Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/ncomms15327 http://scihub22266oqcxt.onion/10.1038/ncomms15327 C5458557!5458557 !28548102     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28548102 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (ä): 15327 Nephropedia Template TP {{tp|p=28548102 |t=2017. Replicating viral vector platform exploits alarmin signals for potent CD8(+) T cell-mediated tumour immunotherapy |pdf=|usr=}}{{28548102 }} gab.com Text Replicating viral vector platform exploits alarmin signals for potent CD8(+) T cell-mediated tumour immunotherapy JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28548102 #FOAvip Viral infections lead to alarmin release and elicit potent cytotoxic effector T lymphocyte (CTL(eff)) responses. Conversely, the induction of protective tumour-specific CTL(eff) and their recruitment into the tumour remain challenging tasks. Here we show that lymphocytic choriomeningitis virus (LCMV) can be engineered to serve as a replication competent, stably-attenuated immunotherapy vector (artLCMV). artLCMV delivers tumour-associated antigens to dendritic cells for efficient CTL priming. Unlike replication-deficient vectors, artLCMV targets also lymphoid tissue stroma cells expressing the alarmin interleukin-33. By triggering interleukin-33 signals, artLCMV elicits CTL(eff) responses of higher magnitude and functionality than those induced by replication-deficient vectors. Superior anti-tumour efficacy of artLCMV immunotherapy depends on interleukin-33 signalling, and a massive CTL(eff) influx triggers an inflammatory conversion of the tumour microenvironment. Our observations suggest that replicating viral delivery systems can release alarmins for improved anti-tumour efficacy. These mechanistic insights may outweigh safety concerns around replicating viral vectors in cancer immunotherapy. Twit Text FOAVip Replicating viral vector platform exploits alarmin signals for potent CD8(+) T cell-mediated tumour immunotherapy ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28548102 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28548102 #FOAvip English Wikipedia <ref>{{Cite pmid|28548102 }}</ref> Replicating viral vector platform exploits alarmin signals for potent CD8(+) T cell-mediated tumour immunotherapy #MMPMID28548102 Kallert SM ; Darbre S ; Bonilla WV ; Kreutzfeldt M ; Page N ; Müller P ; Kreuzaler M ; Lu M ; Favre S ; Kreppel F ; Löhning M ; Luther SA ; Zippelius A ; Merkler D ; Pinschewer DD Nat Commun 2017[May]; 8 (ä): 15327 PMID28548102 show ga Viral infections lead to alarmin release and elicit potent cytotoxic effector T lymphocyte (CTL(eff)) responses. Conversely, the induction of protective tumour-specific CTL(eff) and their recruitment into the tumour remain challenging tasks. Here we show that lymphocytic choriomeningitis virus (LCMV) can be engineered to serve as a replication competent, stably-attenuated immunotherapy vector (artLCMV). artLCMV delivers tumour-associated antigens to dendritic cells for efficient CTL priming. Unlike replication-deficient vectors, artLCMV targets also lymphoid tissue stroma cells expressing the alarmin interleukin-33. By triggering interleukin-33 signals, artLCMV elicits CTL(eff) responses of higher magnitude and functionality than those induced by replication-deficient vectors. Superior anti-tumour efficacy of artLCMV immunotherapy depends on interleukin-33 signalling, and a massive CTL(eff) influx triggers an inflammatory conversion of the tumour microenvironment. Our observations suggest that replicating viral delivery systems can release alarmins for improved anti-tumour efficacy. These mechanistic insights may outweigh safety concerns around replicating viral vectors in cancer immunotherapy. |Alarmins/*immunology [MESH] |Animals [MESH] |Antigens, Neoplasm/immunology [MESH] |Cancer Vaccines/*immunology/therapeutic use [MESH] |Cell Line, Tumor [MESH] |Dendritic Cells/immunology [MESH] |Gene Expression Profiling [MESH] |Genetic Engineering [MESH] |Genetic Vectors/genetics/immunology/therapeutic use [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Immunotherapy/*methods [MESH] |Interleukin-33/genetics/immunology [MESH] |Lymphocyte Activation/immunology [MESH] |Lymphocytic choriomeningitis virus/*genetics [MESH] |Mesocricetus [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C57BL [MESH] |Mice, Inbred DBA [MESH] |Mice, Knockout [MESH] |Neoplasms/immunology/*therapy [MESH] |T-Lymphocytes, Cytotoxic/*immunology [MESH] |Tumor Microenvironment/immunology [MESH] |Vaccines, Live, Unattenuated/immunology [MESH] |Virus Replication/genetics/immunology [MESH]Replicating viral vector platform exploits alarmin signals for potent (epmc).pdf DeepDyve Pubget Overpricing