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10.1002/2211-5463.12221 http://scihub22266oqcxt.onion/10.1002/2211-5463.12221 C5458462!5458462!28593136     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEBS+Open+Bio 2017 ; 7 (6): 811-20 Nephropedia Template TP {{tp|p=28593136|t=2017. AMP?activated protein kinase regulates lipid metabolism and the fibrotic phenotype of hepatic stellate cells through inhibition of autophagy |pdf=|usr=}}{{28593136}} gab.com Text AMP activated protein kinase regulates lipid metabolism and the fibrotic phenotype of hepatic stellate cells through inhibition of autophagy JO: FEBS Open Bio http://www.kidney.de/pget.php?&tw=1&pmid=28593136 #FOAvip Hepatic stellate cells (HSCs) are the principal hepatic cell type responsible for liver fibrosis. Although AMP?activated protein kinase (AMPK) is known to regulate the activation of HSCs, little is known about its underlying molecular mechanisms. In the present study, we demonstrate that AMPK activation by 5?aminoimidazole?4?carboxamide?1?4?ribofuranoside (AICAR) restricts the fibrotic potential elicited by transforming growth factor ? (TGF??) in LX?2 cells through modulation of autophagy. AICAR treatment activated the mechanistic target of rapamycin/Akt pathway and thus inhibited autophagy flux and lipid droplet degradation in lysosomes induced by TGF??. Pretreatment with the autophagy inducer rapamycin reversed the effects of AMPK, further confirming that AICAR inhibited TGF???induced HSC activation via the regulation of autophagy flux. Our study indicates that AICAR exerts its anti?fibrotic and anti?lipid depletion effect, at least in part, by inhibiting TGF???induced autophagy flux. Twit Text FOAVip AMP activated protein kinase regulates lipid metabolism and the fibrotic phenotype of hepatic stellate cells through inhibition of autophagy ????FEBS Open Bio http://www.kidney.de/pget.php?&tw=1&pmid=28593136 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28593136 #FOAvip English Wikipedia <ref>{{Cite pmid|28593136}}</ref> AMP?activated protein kinase regulates lipid metabolism and the fibrotic phenotype of hepatic stellate cells through inhibition of autophagy #MMPMID28593136 Chen M; Liu J; Yang L; Ling W FEBS Open Bio 2017[Jun]; 7 (6): 811-20 PMID28593136show ga Hepatic stellate cells (HSCs) are the principal hepatic cell type responsible for liver fibrosis. Although AMP?activated protein kinase (AMPK) is known to regulate the activation of HSCs, little is known about its underlying molecular mechanisms. In the present study, we demonstrate that AMPK activation by 5?aminoimidazole?4?carboxamide?1?4?ribofuranoside (AICAR) restricts the fibrotic potential elicited by transforming growth factor ? (TGF??) in LX?2 cells through modulation of autophagy. AICAR treatment activated the mechanistic target of rapamycin/Akt pathway and thus inhibited autophagy flux and lipid droplet degradation in lysosomes induced by TGF??. Pretreatment with the autophagy inducer rapamycin reversed the effects of AMPK, further confirming that AICAR inhibited TGF???induced HSC activation via the regulation of autophagy flux. Our study indicates that AICAR exerts its anti?fibrotic and anti?lipid depletion effect, at least in part, by inhibiting TGF???induced autophagy flux. äAMP?activated protein kinase regulates lipid metabolism and the fibrot(epmc).pdf DeepDyve Pubget Overpricing