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10.18632/oncotarget.16762 http://scihub22266oqcxt.onion/10.18632/oncotarget.16762 C5458268!5458268 !28410192     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28410192 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (19 ): 32055-32067 Nephropedia Template TP {{tp|p=28410192 |t=2017. Pellino 1 inactivates mitotic spindle checkpoint by targeting BubR1 for ubiquitinational degradation |pdf=|usr=}}{{28410192 }} gab.com Text Pellino 1 inactivates mitotic spindle checkpoint by targeting BubR1 for ubiquitinational degradation JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28410192 #FOAvip Aberrant constitutive activation of receptor-mediated downstream signalling plays an active role in the deregulation of cell cycle control. The mitotic spindle checkpoint is important in preventing abnormal mitotic cell cycle with chromosome missegregation from achieving neoplastic aneuploidy. However, mechanisms coupling receptor-mediated signalling to mitotic spindle checkpoint regulation remain unclear. Pellino 1 is a receptor signal-responsive E3 ubiquitin ligase, and the application of certain receptor-mediated signalling regulates the expression and activity of Pellino 1. In the present study, Pellino 1 expression induced extensive chromosome aneuploidy and allowed abnormal mitotic cells to adapt and become aneuploid in vitro and in vivo. Pellino 1 directly interacted with BubR1, a key component of mitotic spindle checkpoint, in a mitotic cell-cycle dependent manner, and down-regulated the stability of BubR1 by ubiquitination-mediated degradation and induced mitotic dysfunction. In summary, Pellino 1 expression acts as an inhibitory signal of the homeostatic regulation of mitotic cell cycle and checkpoint, and thus contributes to the initiation and progression of neoplastic chromosome aneuploidy. Twit Text FOAVip Pellino 1 inactivates mitotic spindle checkpoint by targeting BubR1 for ubiquitinational degradation ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28410192 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28410192 #FOAvip English Wikipedia <ref>{{Cite pmid|28410192 }}</ref> Pellino 1 inactivates mitotic spindle checkpoint by targeting BubR1 for ubiquitinational degradation #MMPMID28410192 Park J ; Park HY ; Kim S ; Kim HS ; Park JY ; Go H ; Lee CW Oncotarget 2017[May]; 8 (19 ): 32055-32067 PMID28410192 show ga Aberrant constitutive activation of receptor-mediated downstream signalling plays an active role in the deregulation of cell cycle control. The mitotic spindle checkpoint is important in preventing abnormal mitotic cell cycle with chromosome missegregation from achieving neoplastic aneuploidy. However, mechanisms coupling receptor-mediated signalling to mitotic spindle checkpoint regulation remain unclear. Pellino 1 is a receptor signal-responsive E3 ubiquitin ligase, and the application of certain receptor-mediated signalling regulates the expression and activity of Pellino 1. In the present study, Pellino 1 expression induced extensive chromosome aneuploidy and allowed abnormal mitotic cells to adapt and become aneuploid in vitro and in vivo. Pellino 1 directly interacted with BubR1, a key component of mitotic spindle checkpoint, in a mitotic cell-cycle dependent manner, and down-regulated the stability of BubR1 by ubiquitination-mediated degradation and induced mitotic dysfunction. In summary, Pellino 1 expression acts as an inhibitory signal of the homeostatic regulation of mitotic cell cycle and checkpoint, and thus contributes to the initiation and progression of neoplastic chromosome aneuploidy. |*Cell Cycle Checkpoints [MESH] |Aneuploidy [MESH] |Animals [MESH] |Gene Expression [MESH] |HeLa Cells [MESH] |Humans [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Microtubules/metabolism [MESH] |Mitosis [MESH] |Nuclear Proteins/genetics/*metabolism [MESH] |Protein Binding [MESH] |Protein Serine-Threonine Kinases/*metabolism [MESH] |Protein Transport [MESH] |Proteolysis [MESH] |Signal Transduction [MESH] |Spindle Apparatus/*metabolism [MESH] |Ubiquitin-Protein Ligases/genetics/*metabolism [MESH]Pellino 1 inactivates mitotic spindle checkpoint by targeting BubR1 fo(epmc).pdf DeepDyve Pubget Overpricing