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10.1038/ncomms15402 http://scihub22266oqcxt.onion/10.1038/ncomms15402 C5458103!5458103 !28537251     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28537251 &cmd=llinks): Failed to open stream: HTTP request failed! 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Antigen-specific CD8(+) T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin |pdf=|usr=}}{{28537251 }} gab.com Text Antigen-specific CD8(+) T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28537251 #FOAvip The connection between innate and adaptive immunity is best exemplified by antigen presentation. Although antigen-presenting cells (APCs) are required for antigen receptor-mediated T-cell activation, how T-cells feedback to APCs to sustain an antigen-specific immune response is not completely clear. Here we show that CD8(+) T-cell (also called cytotoxic T lymphocytes, CTL) feedback activates the NLRP3 inflammasome in APCs in an antigen-dependent manner to promote IL-1? maturation. Perforin from antigen-specific CTLs is required for NLRP3 inflammasome activation in APCs. Furthermore, such activation of NLRP3 inflammasome contributes to the induction of antigen-specific antitumour immunity and pathogenesis of graft-versus-host diseases. Our study reveals a positive feedback loop between antigen-specific CTLs and APC to amplify adaptive immunity. Twit Text FOAVip Antigen-specific CD8(+) T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28537251 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28537251 #FOAvip English Wikipedia <ref>{{Cite pmid|28537251 }}</ref> Antigen-specific CD8(+) T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin #MMPMID28537251 Yao Y ; Chen S ; Cao M ; Fan X ; Yang T ; Huang Y ; Song X ; Li Y ; Ye L ; Shen N ; Shi Y ; Li X ; Wang F ; Qian Y Nat Commun 2017[May]; 8 (ä): 15402 PMID28537251 show ga The connection between innate and adaptive immunity is best exemplified by antigen presentation. Although antigen-presenting cells (APCs) are required for antigen receptor-mediated T-cell activation, how T-cells feedback to APCs to sustain an antigen-specific immune response is not completely clear. Here we show that CD8(+) T-cell (also called cytotoxic T lymphocytes, CTL) feedback activates the NLRP3 inflammasome in APCs in an antigen-dependent manner to promote IL-1? maturation. Perforin from antigen-specific CTLs is required for NLRP3 inflammasome activation in APCs. Furthermore, such activation of NLRP3 inflammasome contributes to the induction of antigen-specific antitumour immunity and pathogenesis of graft-versus-host diseases. Our study reveals a positive feedback loop between antigen-specific CTLs and APC to amplify adaptive immunity. |Adaptive Immunity [MESH] |Animals [MESH] |Bone Marrow Cells [MESH] |Bone Marrow Transplantation [MESH] |Cell Line, Tumor [MESH] |Cytotoxicity, Immunologic [MESH] |Dendritic Cells/immunology/metabolism [MESH] |Disease Models, Animal [MESH] |Graft vs Host Disease/*immunology [MESH] |Humans [MESH] |Inflammasomes/*immunology/metabolism [MESH] |Interleukin-1beta/immunology/metabolism [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/genetics/*immunology/metabolism [MESH] |Neoplasms/*immunology [MESH] |Perforin/genetics/immunology/*metabolism [MESH] |T-Lymphocytes, Cytotoxic/*immunology [MESH]Antigen-specific CD8(+) T cell feedback activates NLRP3 inflammasome i(epmc).pdf DeepDyve Pubget Overpricing