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2017 ; 7
(1
): 2710
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Prevalence of chronic kidney disease markers: Evidence from a three-million
married population with fertility desire in rural China
#MMPMID28578426
Du Y
; Zhang S
; Hu M
; Wang Q
; Shen H
; Zhang Y
; Yan D
; Li Y
; Zhang M
; Meng Q
Sci Rep
2017[Jun]; 7
(1
): 2710
PMID28578426
show ga
We aimed to assess the prevalence of chronic kidney diseases (CKD) markers among
the married residents with fertility desire in rural China. Demographic and
clinical data were collected from the National Free Pre-Conception Health
Examination Project. Estimated glomerular filtration rate
(eGFR)?60?mL/min//1.73?m(2), proteinuria, and hematuria were defined as markers
of CKD. GFR was evaluated by using serum creatinine level and the Asian-modified
CKD epidemiology collaboration equation. Automated urine dry chemical and
microscopic analyses were employed to identify proteinuria and hematuria. The
prevalence of CKD markers was 2.92% in the 3,091,379 participants.
eGFR?60?mL/min//1.73?m(2), hematuria and proteinuria was observed in 0.85%,
1.41% and 0.71%, respectively. The prevalence of CKD markers varied greatly
across different geographical locations, which was the highest in the Eastern
Region (3.86%; 95% confidence interval [CI]: 3.81-3.91%), moderate in the Central
Region (2.80%; 95% CI: 2.77-2.82%), and lowest in the Western Region (2.62%; 95%
CI: 2.59-2.65%). Hypertension, obesity, positive hepatitis B virus surface
antigen (HBsAg), age (increased by every 5 years), female gender, and living area
were potential risk factors for CKD. In rural China, the prevalence of CKD
markers in the married couples with fertility desire is low.