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Assessment of the diagnostic value of different biomarkers in relation to various
stages of diabetic nephropathy in type 2 diabetic patients
#MMPMID28577020
Al-Rubeaan K
; Siddiqui K
; Al-Ghonaim MA
; Youssef AM
; Al-Sharqawi AH
; AlNaqeb D
Sci Rep
2017[Jun]; 7
(1
): 2684
PMID28577020
show ga
Albuminuria is widely used to indicate early phases of diabetic nephropathy
although it is limited by the fact that structural damage might precede albumin
excretion. This necessitates identifying better biomarkers that diagnose or
predict diabetic nephropathy. This is a cross-sectional hospital based study
recruiting type 2 diabetic patients cohort aged 35-75 years with diabetes
duration of ?10 years. Out of total eligible 467 patients, 200 patients were with
normal albumin excretion, 184 patients with microalbuminuria and 83 patients with
macroalbuminuria. All the patients were tested for the 22 selected biomarkers
including serum, plasma and urinary markers. Sensitivity, specificity, and area
under the curve (AUC) were calculated as measures of diagnostic accuracy. Out of
the tested biomarkers, urinary transferrin, urinary Retinol binding protein (RBP)
and serum osteopontin had the best diagnostic value for diabetic nephropathy
presence based on the AUC value. The rest of the biomarkers had comparatively
less or even no discriminative power. The urinary transferrin and RBP and serum
osteopontin, had the best diagnostic value in type 2 diabetic patients at
different stages of diabetic nephropathy. Further longitudinal prospective
studies are needed to evaluate the predictive power of those markers for
detecting diabetic nephropathy before any structural damage occurs.
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