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2016 ; 9
(11
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Additive Manufacturing of Patient-Customizable Scaffolds for Tubular Tissues
Using the Melt-Drawing Method
#MMPMID28774013
Tan YJ
; Tan X
; Yeong WY
; Tor SB
Materials (Basel)
2016[Nov]; 9
(11
): ä PMID28774013
show ga
Polymeric fibrous scaffolds for guiding cell growth are designed to be
potentially used for the tissue engineering (TE) of tubular organs including
esophagi, blood vessels, tracheas, etc. Tubular scaffolds were fabricated via
melt-drawing of highly elastic poly(l-lactide-co-?-caprolactone) (PLC) fibers
layer-by-layer on a cylindrical mandrel. The diameter and length of the scaffolds
are customizable via 3D printing of the mandrel. Thickness of the scaffolds was
varied by changing the number of layers of the melt-drawing process. The
morphology and tensile properties of the PLC fibers were investigated. The fibers
were highly aligned with a uniform diameter. Their diameters and tensile
properties were tunable by varying the melt-drawing speeds. These tailorable
topographies and tensile properties show that the additive-based scaffold
fabrication technique is customizable at the micro- and macro-scale for different
tubular tissues. The merits of these scaffolds in TE were further shown by the
finding that myoblast and fibroblast cells seeded onto the scaffolds in vitro
showed appropriate cell proliferation and distribution. Human mesenchymal stem
cells (hMSCs) differentiated to smooth muscle lineage on the microfibrous
scaffolds in the absence of soluble induction factors, showing cellular shape
modulation and scaffold elasticity may encourage the myogenic differentiation of
stem cells.