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2016 ; 9
(6
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Inhibition of Cariogenic Plaque Formation on Root Surface with
Polydopamine-Induced-Polyethylene Glycol Coating
#MMPMID28773535
Mei ML
; Li QL
; Chu CH
Materials (Basel)
2016[May]; 9
(6
): ä PMID28773535
show ga
Root caries prevention has been a challenge for clinicians due to its special
anatomical location, which favors the accumulation of dental plaque. Researchers
are looking for anti-biofouling material to inhibit bacterial growth on exposed
root surfaces. This study aimed to develop polydopamine-induced-polyethylene
glycol (PEG) and to study its anti-biofouling effect against a multi-species
cariogenic biofilm on the root dentine surface. Hydroxyapatite disks and human
dentine blocks were divided into four groups for experiments. They received
polydopamine-induced-PEG, PEG, polydopamine, or water application. Contact angle,
quartz crystal microbalance, and Fourier transform infrared spectroscopy were
used to study the wetting property, surface affinity, and an infrared spectrum;
the results indicated that PEG was induced by polydopamine onto a hydroxyapatite
disk. Salivary mucin absorption on hydroxyapatite disks with
polydopamine-induced-PEG was confirmed using spectrophotometry. The growth of a
multi-species cariogenic biofilm on dentine blocks with polydopamine-induced-PEG
was assessed and monitored by colony-forming units, confocal laser scanning
microscopy, and scanning electron microscopy. The results showed that dentine
with polydopamine-induced-PEG had fewer bacteria than other groups. In
conclusion, a novel polydopamine-induced-PEG coating was developed. Its
anti-biofouling effect inhibited salivary mucin absorption and cariogenic biofilm
formation on dentine surface and thus may be used for the prevention of root
dentine caries.