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10.3390/ma9030198

http://scihub22266oqcxt.onion/10.3390/ma9030198
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suck abstract from ncbi


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pmid28773321
      Materials+(Basel) 2016 ; 9 (3 ): ä
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  • Development and Characterization of a Bioinspired Bone Matrix with Aligned Nanocrystalline Hydroxyapatite on Collagen Nanofibers #MMPMID28773321
  • Wu HC ; Wang TW ; Sun JS ; Lee YH ; Shen MH ; Tsai ZR ; Chen CY ; Hsu HC
  • Materials (Basel) 2016[Mar]; 9 (3 ): ä PMID28773321 show ga
  • Various kinds of three-dimensional (3D) scaffolds have been designed to mimic the biological spontaneous bone formation characteristics by providing a suitable microenvironment for osteogenesis. In view of this, a natural bone-liked composite scaffold, which was combined with inorganic (hydroxyapatite, Hap) and organic (type I collagen, Col) phases, has been developed through a self-assembly process. This 3D porous scaffold consisting of a c-axis of Hap nanocrystals (nHap) aligning along Col fibrils arrangement is similar to natural bone architecture. A significant increase in mechanical strength and elastic modulus of nHap/Col scaffold is achieved through biomimetic mineralization process when compared with simple mixture of collagen and hydroxyapatite method. It is suggested that the self-organization of Hap and Col produced in vivo could also be achieved in vitro. The oriented nHap/Col composite not only possesses bone-like microstructure and adequate mechanical properties but also enhances the regeneration and reorganization abilities of bone tissue. These results demonstrated that biomimetic nHap/Col can be successfully reconstructed as a bone graft substitute in bone tissue engineering.
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