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10.3390/diseases5010011 http://scihub22266oqcxt.onion/10.3390/diseases5010011 C5456333!5456333!28933364     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diseases 2017 ; 5 (1): ä Nephropedia Template TP {{tp|p=28933364|t=2017. Targeting H19, an Imprinted Long Non-Coding RNA, in Hepatic Functions and Liver Diseases |pdf=|usr=}}{{28933364}} gab.com Text Targeting H19, an Imprinted Long Non-Coding RNA, in Hepatic Functions and Liver Diseases JO: Diseases http://www.kidney.de/pget.php?&tw=1&pmid=28933364 #FOAvip H19 is a long non-coding RNA regulated by genomic imprinting through methylation at the locus between H19 and IGF2. H19 is important in normal liver development, controlling proliferation and impacting genes involved in an important network controlling fetal development. H19 also plays a major role in disease progression, particularly in hepatocellular carcinoma. H19 participates in the epigenetic regulation of many processes impacting diseases, such as activating the miR-200 pathway by histone acetylation to inhibit the epithelial-mesenchymal transition to suppress tumor metastasis. Furthermore, H19?s normal regulation is disturbed in diseases, such as hepatocellular carcinoma. In this disease, aberrant epigenetic maintenance results in biallelic expression of IGF2, leading to uncontrolled cellular proliferation. This review aims to further research utilizing H19 for drug discovery and the treatment of liver diseases by focusing on both the epigenetic regulation of H19 and how H19 regulates normal liver functions and diseases, particularly by epigenetic mechanisms. Twit Text FOAVip Targeting H19, an Imprinted Long Non-Coding RNA, in Hepatic Functions and Liver Diseases ????Diseases http://www.kidney.de/pget.php?&tw=1&pmid=28933364 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28933364 #FOAvip English Wikipedia <ref>{{Cite pmid|28933364}}</ref> Targeting H19, an Imprinted Long Non-Coding RNA, in Hepatic Functions and Liver Diseases #MMPMID28933364 Pope C; Mishra S; Russell J; Zhou Q; Zhong XB Diseases 2017[Mar]; 5 (1): ä PMID28933364show ga H19 is a long non-coding RNA regulated by genomic imprinting through methylation at the locus between H19 and IGF2. H19 is important in normal liver development, controlling proliferation and impacting genes involved in an important network controlling fetal development. H19 also plays a major role in disease progression, particularly in hepatocellular carcinoma. H19 participates in the epigenetic regulation of many processes impacting diseases, such as activating the miR-200 pathway by histone acetylation to inhibit the epithelial-mesenchymal transition to suppress tumor metastasis. Furthermore, H19?s normal regulation is disturbed in diseases, such as hepatocellular carcinoma. In this disease, aberrant epigenetic maintenance results in biallelic expression of IGF2, leading to uncontrolled cellular proliferation. This review aims to further research utilizing H19 for drug discovery and the treatment of liver diseases by focusing on both the epigenetic regulation of H19 and how H19 regulates normal liver functions and diseases, particularly by epigenetic mechanisms. äTargeting H19, an Imprinted Long Non-Coding RNA, in Hepatic Functions (epmc).pdf DeepDyve Pubget Overpricing