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Plasma brain-derived neurotrophic factor concentration is a predictor of chronic
kidney disease in patients with cardiovascular risk factors - Hyogo Sleep
Cardio-Autonomic Atherosclerosis study
#MMPMID28575038
Kurajoh M
; Kadoya M
; Morimoto A
; Miyoshi A
; Kanzaki A
; Kakutani-Hatayama M
; Hamamoto K
; Shoji T
; Moriwaki Y
; Yamamoto T
; Inaba M
; Namba M
; Koyama H
PLoS One
2017[]; 12
(6
): e0178686
PMID28575038
show ga
BACKGROUND: Brain-derived neurotrophic factor (BDNF) has been shown to have
protective effects against cardiovascular diseases and death through neural and
non-neural pathways via tropomyosin-related kinase B signaling. However, it is
not known whether plasma BDNF concentration is a predictor of chronic kidney
disease (CKD). DESIGN: This study was conducted as a prospective cohort study as
part of the Hyogo Sleep Cardio-Autonomic Atherosclerosis. METHODS: We measured
plasma BDNF concentration in 324 patients without CKD, defined as an estimated
glomerular filtration rate (eGFR) less than 60 ml/min/1.73m2, and with
cardiovascular risk factors. As potential confounders, sleep condition, nocturnal
hypertension, and autonomic function were quantitatively examined. The patients
were followed for a median 37 months (range 2-59 months) and occurrence of CKD
was noted. RESULTS: Plasma BDNF concentration was significantly and independently
associated with CKD development, which occurred in 38 patients (11.7%).
Kaplan-Meier analysis revealed that patients with reduced plasma BDNF
concentration exhibited a significantly (p = 0.029) greater number of CKD events
as compared to those with a higher concentration. Moreover, comparisons of key
subgroups showed that the risk of CKD in association with low plasma BDNF
concentration was more prominent in patients with a greater reduction of
nocturnal systolic blood pressure, better movement index, higher standard
deviations of the NN(RR) interval or average NN(RR) interval for each 5-minute
period, and without past cardiovascular disease events, smoking habit, or
albuminuria. CONCLUSIONS: Plasma BDNF concentration is an independent predictor
for development of CKD in patients with cardiovascular risk factors.
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