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10.1038/ncb3528 http://scihub22266oqcxt.onion/10.1038/ncb3528 C5455977!5455977 !28530658     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28530658 &cmd=llinks): Failed to open stream: HTTP request failed! 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Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues |pdf=|usr=}}{{28530658 }} gab.com Text Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28530658 #FOAvip The hierarchical organization of properly sized blood vessels ensures the correct distribution of blood to all organs of the body, and is controlled via haemodynamic cues. In current concepts, an endothelium-dependent shear stress set point causes blood vessel enlargement in response to higher flow rates, while lower flow would lead to blood vessel narrowing, thereby establishing homeostasis. We show that during zebrafish embryonic development increases in flow, after an initial expansion of blood vessel diameters, eventually lead to vessel contraction. This is mediated via endothelial cell shape changes. We identify the transforming growth factor beta co-receptor endoglin as an important player in this process. Endoglin mutant cells and blood vessels continue to enlarge in response to flow increases, thus exacerbating pre-existing embryonic arterial-venous shunts. Together, our data suggest that cell shape changes in response to biophysical cues act as an underlying principle allowing for the ordered patterning of tubular organs. Twit Text FOAVip Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28530658 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28530658 #FOAvip English Wikipedia <ref>{{Cite pmid|28530658 }}</ref> Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues #MMPMID28530658 Sugden WW ; Meissner R ; Aegerter-Wilmsen T ; Tsaryk R ; Leonard EV ; Bussmann J ; Hamm MJ ; Herzog W ; Jin Y ; Jakobsson L ; Denz C ; Siekmann AF Nat Cell Biol 2017[Jun]; 19 (6 ): 653-665 PMID28530658 show ga The hierarchical organization of properly sized blood vessels ensures the correct distribution of blood to all organs of the body, and is controlled via haemodynamic cues. In current concepts, an endothelium-dependent shear stress set point causes blood vessel enlargement in response to higher flow rates, while lower flow would lead to blood vessel narrowing, thereby establishing homeostasis. We show that during zebrafish embryonic development increases in flow, after an initial expansion of blood vessel diameters, eventually lead to vessel contraction. This is mediated via endothelial cell shape changes. We identify the transforming growth factor beta co-receptor endoglin as an important player in this process. Endoglin mutant cells and blood vessels continue to enlarge in response to flow increases, thus exacerbating pre-existing embryonic arterial-venous shunts. Together, our data suggest that cell shape changes in response to biophysical cues act as an underlying principle allowing for the ordered patterning of tubular organs. |*Cell Shape [MESH] |*Hemodynamics [MESH] |*Mechanotransduction, Cellular [MESH] |Animals [MESH] |Arteriovenous Malformations/genetics/metabolism/physiopathology [MESH] |Endoglin/deficiency/genetics/*metabolism [MESH] |Endothelial Cells/*metabolism [MESH] |Genetic Predisposition to Disease [MESH] |Human Umbilical Vein Endothelial Cells/metabolism [MESH] |Humans [MESH] |Kruppel-Like Transcription Factors/genetics/metabolism [MESH] |Mice, Knockout [MESH] |Mutation [MESH] |Neovascularization, Physiologic [MESH] |Phenotype [MESH] |Regional Blood Flow [MESH] |Stress, Mechanical [MESH] |Time Factors [MESH] |Zebrafish Proteins/genetics/*metabolism [MESH]Endoglin controls blood vessel diameter through endothelial cell shape(epmc).pdf DeepDyve Pubget Overpricing