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10.1016/j.devcel.2016.07.014 http://scihub22266oqcxt.onion/10.1016/j.devcel.2016.07.014 C5455786!5455786!27569419     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Dev+Cell 2016 ; 38 (5): 453-62 Nephropedia Template TP {{tp|p=27569419|t=2016. Oxidant Sensing by TRPM2 Inhibits Neutrophil Migration and Mitigates Inflammation |pdf=|usr=}}{{27569419}} gab.com Text Oxidant Sensing by TRPM2 Inhibits Neutrophil Migration and Mitigates Inflammation JO: Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=27569419 #FOAvip Blood neutrophils perform an essential host-defense function by directly migrating to bacterial invasion sites to kill bacteria. The mechanisms mediating the transition from the migratory to bactericidal phenotype remain elusive. Here, we demonstrate that TRPM2, a trp superfamily member, senses neutrophil-generated reactive oxygen species and restrains neutrophil migration. The inhibitory function of oxidant sensing by TRPM2 requires the oxidation of Cys549, which then induces TRMP2 binding to formyl peptide receptor 1 (FPR1) and subsequent FPR1 internalization and signaling inhibition. The oxidant sensing-induced termination of neutrophil migration at the site of infection permits a smooth transition to the subsequent microbial killing phase. Twit Text FOAVip Oxidant Sensing by TRPM2 Inhibits Neutrophil Migration and Mitigates Inflammation ????Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=27569419 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27569419 #FOAvip English Wikipedia <ref>{{Cite pmid|27569419}}</ref> Oxidant Sensing by TRPM2 Inhibits Neutrophil Migration and Mitigates Inflammation #MMPMID27569419 Wang G; Cao L; Liu X; Sieracki NA; Di A; Wen X; Chen Y; Taylor S; Huang X; Tiruppathi C; Zhao Yy; Song Y; Gao X; Jin T; Bai C; Malik AB; Xu J Dev Cell 2016[Sep]; 38 (5): 453-62 PMID27569419show ga Blood neutrophils perform an essential host-defense function by directly migrating to bacterial invasion sites to kill bacteria. The mechanisms mediating the transition from the migratory to bactericidal phenotype remain elusive. Here, we demonstrate that TRPM2, a trp superfamily member, senses neutrophil-generated reactive oxygen species and restrains neutrophil migration. The inhibitory function of oxidant sensing by TRPM2 requires the oxidation of Cys549, which then induces TRMP2 binding to formyl peptide receptor 1 (FPR1) and subsequent FPR1 internalization and signaling inhibition. The oxidant sensing-induced termination of neutrophil migration at the site of infection permits a smooth transition to the subsequent microbial killing phase. äOxidant Sensing by TRPM2 Inhibits Neutrophil Migration and Mitigates I(epmc).pdf DeepDyve Pubget Overpricing