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Role of the lysophospholipid mediators lysophosphatidic acid and sphingosine
1-phosphate in lung fibrosis
#MMPMID22802282
Shea BS
; Tager AM
Proc Am Thorac Soc
2012[Jul]; 9
(3
): 102-10
PMID22802282
show ga
Aberrant wound healing responses to lung injury are believed to contribute to
fibrotic lung diseases, such as idiopathic pulmonary fibrosis (IPF). The
lysophospholipids lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P),
by virtue of their ability to mediate many basic cellular functions, including
survival, proliferation, migration, and contraction, can influence many of the
biological processes involved in wound healing. Accordingly, recent
investigations indicate that LPA and S1P may play critical roles in regulating
the development of lung fibrosis. Here we review the evidence indicating that LPA
and S1P regulate pulmonary fibrosis and the potential mechanisms through which
these lysophospholipids may influence fibrogenesis induced by lung injury.
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