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10.1165/rcmb.2012-0525OC http://scihub22266oqcxt.onion/10.1165/rcmb.2012-0525OC C5455351!5455351!23947598     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Respir+Cell+Mol+Biol 2014 ; 50 (1): 87-95 Nephropedia Template TP {{tp|p=23947598|t=2014. Pivotal Role of the 5-Lipoxygenase Pathway in Lung Injury after Experimental Sepsis |pdf=|usr=}}{{23947598}} gab.com Text Pivotal Role of the 5-Lipoxygenase Pathway in Lung Injury after Experimental Sepsis JO: Am J Respir Cell Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=23947598 #FOAvip Postsepsis lung injury is a common clinical problem associated with significant morbidity and mortality. Leukotrienes (LTs) are important lipid mediators of infection and inflammation derived from the 5-lipoxygenase (5-LO) metabolism of arachidonate with the potential to contribute to lung damage after sepsis. To test the hypothesis that LTs are mediators of lung injury after sepsis, we assessed lung structure, inflammatory mediators, and mechanical changes after cecal ligation and puncture surgery in wild-type (WT) and 5-LO knockout (5-LO?/?) mice and in WT mice treated with a pharmacologic LT synthesis inhibitor (MK886) and LT receptor antagonists (CP105,696 and montelukast). Sixteen hours after surgery, WT animals exhibited severe lung injury (by histological analysis), substantial mechanical impairment (i.e., an increase in static lung elastance), an increase in neutrophil infiltration, and high levels of LTB4, cysteinyl-LTs (cys-LTs), prostaglandin E2, IL-1?, IL-6, IL-10, IL-17, KC (CXCL1), and monocyte chemotactic protein?1 (CCL2) in lung tissue and plasma. 5-LO?/? mice and WT mice treated with a pharmacologic 5-LO inhibitor were significantly protected from lung inflammation and injury. Selective antagonists for BLT1 or cys-LT1, the high-affinity receptors for LTB4 and cys-LTs, respectively, were insufficient to provide protection when used alone. These results point to an important role for 5-LO products in sepsis-induced lung injury and suggest that the use of 5-LO inhibitors may be of therapeutic benefit clinically. Twit Text FOAVip Pivotal Role of the 5-Lipoxygenase Pathway in Lung Injury after Experimental Sepsis ????Am J Respir Cell Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=23947598 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23947598 #FOAvip English Wikipedia <ref>{{Cite pmid|23947598}}</ref> Pivotal Role of the 5-Lipoxygenase Pathway in Lung Injury after Experimental Sepsis #MMPMID23947598 Monteiro APT; Soledade E; Pinheiro CS; Dellatorre-Teixeira L; Oliveira GP; Oliveira MG; Peters-Golden M; Rocco PRM; Benjamim CF; Canetti C Am J Respir Cell Mol Biol 2014[Jan]; 50 (1): 87-95 PMID23947598show ga Postsepsis lung injury is a common clinical problem associated with significant morbidity and mortality. Leukotrienes (LTs) are important lipid mediators of infection and inflammation derived from the 5-lipoxygenase (5-LO) metabolism of arachidonate with the potential to contribute to lung damage after sepsis. To test the hypothesis that LTs are mediators of lung injury after sepsis, we assessed lung structure, inflammatory mediators, and mechanical changes after cecal ligation and puncture surgery in wild-type (WT) and 5-LO knockout (5-LO?/?) mice and in WT mice treated with a pharmacologic LT synthesis inhibitor (MK886) and LT receptor antagonists (CP105,696 and montelukast). Sixteen hours after surgery, WT animals exhibited severe lung injury (by histological analysis), substantial mechanical impairment (i.e., an increase in static lung elastance), an increase in neutrophil infiltration, and high levels of LTB4, cysteinyl-LTs (cys-LTs), prostaglandin E2, IL-1?, IL-6, IL-10, IL-17, KC (CXCL1), and monocyte chemotactic protein?1 (CCL2) in lung tissue and plasma. 5-LO?/? mice and WT mice treated with a pharmacologic 5-LO inhibitor were significantly protected from lung inflammation and injury. Selective antagonists for BLT1 or cys-LT1, the high-affinity receptors for LTB4 and cys-LTs, respectively, were insufficient to provide protection when used alone. These results point to an important role for 5-LO products in sepsis-induced lung injury and suggest that the use of 5-LO inhibitors may be of therapeutic benefit clinically. äPivotal Role of the 5-Lipoxygenase Pathway in Lung Injury after Experi(epmc).pdf DeepDyve Pubget Overpricing