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suck abstract from ncbi


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pmid28584627
      Clin+Kidney+J 2017 ; 10 (2 ): 266-268
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  • Mixed leukocyte cell-derived chemotaxin 2 and amyloid A renal amyloidosis in a Kazakh-German patient #MMPMID28584627
  • Gödecke VA ; Röcken C ; Steinmüller-Magin L ; Nadrowitz F ; Fleig SV ; Haller H ; Wagner AD
  • Clin Kidney J 2017[Apr]; 10 (2 ): 266-268 PMID28584627 show ga
  • Leukocyte cell-derived chemotaxin 2 (LECT2)-related amyloidosis (ALECT2) constitutes a subtype of systemic amyloidosis affecting the kidney. This is the first case describing mixed ALECT2 and Amyloid A renal amyloidosis in a Kazakh-German patient. Genetic analysis shows a polymorphism in the LECT2 gene and a homozygous mutation in the SAA1 gene. Notably, our patient has a body mass index of 61?kg/m(2) and a pathological glucose tolerance test. ALECT2 was found in certain ethnic groups with a high incidence of diabetes. In our case, morbid obesity may have played a significant role in clinical manifestation of ALECT2 amyloidosis.
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