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10.3390/ijms18051010 http://scihub22266oqcxt.onion/10.3390/ijms18051010 C5454923!5454923 !28481295     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28481295 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2017 ; 18 (5 ): ä Nephropedia Template TP {{tp|p=28481295 |t=2017. Inhibiting HDAC1 Enhances the Anti-Cancer Effects of Statins through Downregulation of GGTase-I? Expression |pdf=|usr=}}{{28481295 }} gab.com Text Inhibiting HDAC1 Enhances the Anti-Cancer Effects of Statins through Downregulation of GGTase-I Expression JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28481295 #FOAvip Hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors, namely statins, are potential anti-tumor agents. Previously, we showed that a pan-histone deacetylase (HDAC) inhibitor enhances the anti-tumor effects of the HMG-CoA inhibitor. However, the underlying mechanisms were not fully understood. Cancer cell lines (CAL-27 and SACC-83) were exposed to pan-HDAC inhibitor, or HDAC1 inhibitor, or geranylgeranyl transferase type I (GGTase-I) inhibitor alone or in combination with statin. Cell viability, apoptosis, migration, and invasion were assessed by Cell Count Kit-8, 4',6-diamidino-2-phenylindole staining, and transwell assay, respectively. A xenograft model was used for assessing tumor growth in vivo. Western blot and real-time PCR were used to assess the expression of genes. We observed that inhibiting HDAC1 could enhance the anti-tumor effects of statins both in vitro and in vivo. Inhibiting HDAC1 blocked the statin-induced upregulation of geranylgeranyl transferase type I? subunit (GGTase-I?), resulting in an enhancement of the anti-cancer effects of statin. Overexpression of GGTase-I? or constitutively active RhoA abolished the enhancement by inhibiting HDAC1 on anti-tumor effects of statins. The HDAC1 inhibitor failed to enhance cytotoxicity in non-tumor primary cells treated with statin. Inhibiting HDAC1 enhanced the anti-cancer effects of statins through downregulation of GGTase-I? expression, and thus further inactivation of RhoA. A combination of statin with HDAC1 or GGTase-I inhibitor would be a new strategy for cancer chemotherapy. Twit Text FOAVip Inhibiting HDAC1 Enhances the Anti-Cancer Effects of Statins through Downregulation of GGTase-I Expression ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28481295 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28481295 #FOAvip English Wikipedia <ref>{{Cite pmid|28481295 }}</ref> Inhibiting HDAC1 Enhances the Anti-Cancer Effects of Statins through Downregulation of GGTase-I? Expression #MMPMID28481295 Li R ; Gan YH Int J Mol Sci 2017[May]; 18 (5 ): ä PMID28481295 show ga Hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors, namely statins, are potential anti-tumor agents. Previously, we showed that a pan-histone deacetylase (HDAC) inhibitor enhances the anti-tumor effects of the HMG-CoA inhibitor. However, the underlying mechanisms were not fully understood. Cancer cell lines (CAL-27 and SACC-83) were exposed to pan-HDAC inhibitor, or HDAC1 inhibitor, or geranylgeranyl transferase type I (GGTase-I) inhibitor alone or in combination with statin. Cell viability, apoptosis, migration, and invasion were assessed by Cell Count Kit-8, 4',6-diamidino-2-phenylindole staining, and transwell assay, respectively. A xenograft model was used for assessing tumor growth in vivo. Western blot and real-time PCR were used to assess the expression of genes. We observed that inhibiting HDAC1 could enhance the anti-tumor effects of statins both in vitro and in vivo. Inhibiting HDAC1 blocked the statin-induced upregulation of geranylgeranyl transferase type I? subunit (GGTase-I?), resulting in an enhancement of the anti-cancer effects of statin. Overexpression of GGTase-I? or constitutively active RhoA abolished the enhancement by inhibiting HDAC1 on anti-tumor effects of statins. The HDAC1 inhibitor failed to enhance cytotoxicity in non-tumor primary cells treated with statin. Inhibiting HDAC1 enhanced the anti-cancer effects of statins through downregulation of GGTase-I? expression, and thus further inactivation of RhoA. A combination of statin with HDAC1 or GGTase-I inhibitor would be a new strategy for cancer chemotherapy. |*Down-Regulation [MESH] |Alkyl and Aryl Transferases/*genetics/metabolism [MESH] |Animals [MESH] |Antineoplastic Agents/administration & dosage/*pharmacology/therapeutic use [MESH] |Apoptosis/drug effects [MESH] |Cell Line, Tumor [MESH] |Cell Movement/drug effects [MESH] |Head and Neck Neoplasms/drug therapy [MESH] |Histone Deacetylase 1/*antagonists & inhibitors [MESH] |Histone Deacetylase Inhibitors/administration & dosage/*pharmacology/therapeutic use [MESH] |Human Umbilical Vein Endothelial Cells/drug effects/metabolism [MESH] |Humans [MESH] |Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage/pharmacology/therapeutic use [MESH] |Mice [MESH]Inhibiting HDAC1 Enhances the Anti-Cancer Effects of Statins through (epmc).pdf DeepDyve Pubget Overpricing