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10.3390/ijms18050984 http://scihub22266oqcxt.onion/10.3390/ijms18050984 C5454897!5454897 !28475116     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28475116 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2017 ; 18 (5 ): ä Nephropedia Template TP {{tp|p=28475116 |t=2017. Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention |pdf=|usr=}}{{28475116 }} gab.com Text Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28475116 #FOAvip Advanced glycation end-products (AGEs) are non-enzymatic protein and amino acid adducts as well as DNA adducts which form from dicarbonyls and glucose. AGE formation is enhanced in diabetes and is associated with the development of diabetic complications. In the current review, we discuss mechanisms that lead to enhanced AGE levels in the context of diabetes and diabetic complications. The methylglyoxal-detoxifying glyoxalase system as well as alternative pathways of AGE detoxification are summarized. Therapeutic approaches to interfere with different pathways of AGE formation are presented. Twit Text FOAVip Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28475116 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28475116 #FOAvip English Wikipedia <ref>{{Cite pmid|28475116 }}</ref> Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention #MMPMID28475116 Brings S ; Fleming T ; Freichel M ; Muckenthaler MU ; Herzig S ; Nawroth PP Int J Mol Sci 2017[May]; 18 (5 ): ä PMID28475116 show ga Advanced glycation end-products (AGEs) are non-enzymatic protein and amino acid adducts as well as DNA adducts which form from dicarbonyls and glucose. AGE formation is enhanced in diabetes and is associated with the development of diabetic complications. In the current review, we discuss mechanisms that lead to enhanced AGE levels in the context of diabetes and diabetic complications. The methylglyoxal-detoxifying glyoxalase system as well as alternative pathways of AGE detoxification are summarized. Therapeutic approaches to interfere with different pathways of AGE formation are presented. |Animals [MESH] |Clinical Trials as Topic [MESH] |Diabetes Complications/drug therapy/*metabolism [MESH] |Glycation End Products, Advanced/*metabolism [MESH] |Glyoxal/metabolism [MESH] |Humans [MESH] |Hypoglycemic Agents/pharmacology/*therapeutic use [MESH]Dicarbonyls and Advanced Glycation End-Products in the Development of (epmc).pdf DeepDyve Pubget Overpricing