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10.3390/ijms18050959 http://scihub22266oqcxt.onion/10.3390/ijms18050959 C5454872!5454872 !28468326     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28468326 &cmd=llinks): Failed to open stream: HTTP request failed! 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Subcutaneous and Visceral Adipose Tissue Secretions from Extremely Obese Men and Women both Acutely Suppress Muscle Insulin Signaling |pdf=|usr=}}{{28468326 }} gab.com Text Subcutaneous and Visceral Adipose Tissue Secretions from Extremely Obese Men and Women both Acutely Suppress Muscle Insulin Signaling JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28468326 #FOAvip Adipose tissue plays a key role in the development of type-2 diabetes via the secretion of adipokines. The current study investigated if secretion media derived from intact visceral (VAT) and subcutaneous (SAT) adipose tissues from extremely obese men and women differently suppressed insulin signaling in human skeletal myotubes derived from a healthy, non-diabetic male and female donor, respectively. Adipose tissue samples were collected from men and women during laparoscopic bariatric surgery. In general, secretion media collected from both SAT and VAT depots caused impaired insulin signaling in myotubes, independent of sex. In females, this was true regardless of the protein kinase B (Akt) phosphorylation site (Akt (Thr308) and Akt (Ser473)) assessed (p < 0.01). In males, both SAT and VAT secretion media reduced Akt (Thr308) activation in insulin-stimulated myotubes compared to controls (p < 0.001); however, only the VAT secretion media impaired Akt (Ser473) phosphorylation. Independent of sex, 13 out of 18 detected cytokines, chemokines, and growth factors were more abundant in VAT versus SAT secretion media (p < 0.01). Both SAT and VAT secretion media from obese men and women acutely suppress insulin signaling in myotubes, despite different secretion profiles. We propose that this crosstalk model will help to extend our understanding of the interplay between adipose and muscle, as well as the pathogenesis of type-2 diabetes. Twit Text FOAVip Subcutaneous and Visceral Adipose Tissue Secretions from Extremely Obese Men and Women both Acutely Suppress Muscle Insulin Signaling ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28468326 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28468326 #FOAvip English Wikipedia <ref>{{Cite pmid|28468326 }}</ref> Subcutaneous and Visceral Adipose Tissue Secretions from Extremely Obese Men and Women both Acutely Suppress Muscle Insulin Signaling #MMPMID28468326 Sarr O ; Strohm RJ ; MacDonald TL ; Gaudio N ; Reed JK ; Foute-Nelong J ; Dyck DJ ; Mutch DM Int J Mol Sci 2017[May]; 18 (5 ): ä PMID28468326 show ga Adipose tissue plays a key role in the development of type-2 diabetes via the secretion of adipokines. The current study investigated if secretion media derived from intact visceral (VAT) and subcutaneous (SAT) adipose tissues from extremely obese men and women differently suppressed insulin signaling in human skeletal myotubes derived from a healthy, non-diabetic male and female donor, respectively. Adipose tissue samples were collected from men and women during laparoscopic bariatric surgery. In general, secretion media collected from both SAT and VAT depots caused impaired insulin signaling in myotubes, independent of sex. In females, this was true regardless of the protein kinase B (Akt) phosphorylation site (Akt (Thr308) and Akt (Ser473)) assessed (p < 0.01). In males, both SAT and VAT secretion media reduced Akt (Thr308) activation in insulin-stimulated myotubes compared to controls (p < 0.001); however, only the VAT secretion media impaired Akt (Ser473) phosphorylation. Independent of sex, 13 out of 18 detected cytokines, chemokines, and growth factors were more abundant in VAT versus SAT secretion media (p < 0.01). Both SAT and VAT secretion media from obese men and women acutely suppress insulin signaling in myotubes, despite different secretion profiles. We propose that this crosstalk model will help to extend our understanding of the interplay between adipose and muscle, as well as the pathogenesis of type-2 diabetes. |*Signal Transduction [MESH] |Adipokines/*metabolism [MESH] |Adult [MESH] |Cells, Cultured [MESH] |Chemokines/metabolism [MESH] |Culture Media, Conditioned/pharmacology [MESH] |Female [MESH] |Humans [MESH] |Insulin Resistance [MESH] |Insulin/*metabolism [MESH] |Intra-Abdominal Fat/*metabolism [MESH] |Male [MESH] |Middle Aged [MESH] |Muscle Fibers, Skeletal/drug effects/*metabolism [MESH] |Obesity, Morbid/*metabolism [MESH] |Sex Factors [MESH]Subcutaneous and Visceral Adipose Tissue Secretions from Extremely Obe(epmc).pdf DeepDyve Pubget Overpricing