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A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41598-017-02354-3 http://scihub22266oqcxt.onion/10.1038/s41598-017-02354-3 C5453949!5453949 !28572624     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28572624 &cmd=llinks): Failed to open stream: HTTP request failed! 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Diacylglycerol Kinase alpha is Involved in the Vitamin E-Induced Amelioration of Diabetic Nephropathy in Mice |pdf=|usr=}}{{28572624 }} gab.com Text Diacylglycerol Kinase alpha is Involved in the Vitamin E-Induced Amelioration of Diabetic Nephropathy in Mice JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28572624 #FOAvip Diabetic nephropathy (DN) is one of vascular complications of diabetes and is caused by abnormal protein kinase C activation as a result of increased diacylglycerol (DG) production in diabetic hyperglycaemia. Diacylglycerol kinase (DGK) converts DG into phosphatidic acid. Therefore, it is expected that the activation of DGK would ameliorate DN. Indeed, it has been reported that vitamin E (VtE) ameliorates DN in rat by activating DGK, and we recently reported that VtE specifically activates DGK? isoform in vitro. However, whether DGK? is involved in the VtE-induced amelioration of DN in vivo remains unknown. Therefore, we investigated the VtE-induced amelioration of DN in wild-type (DGK?(+/+)) and DGK?-deficient (DGK?(-/-)) mice in which diabetes was induced by streptozocin. Several symptoms of DN were ameliorated by VtE treatment in the DGK?(+/+) mice but not in the DGK?(-/-) mice. Moreover, transmission electron microscopy of glomeruli and immunofluorescent staining of glomerular epithelial cells (podocytes) indicated that VtE ameliorates podocyte pathology and prevents podocyte loss in the DGK?(+/+) mice but not in the DGK?(-/-) mice. We showed that VtE can ameliorate DN in mice and that DGK? is involved in the VtE-induced amelioration of DN in vivo, suggesting that DGK? is an attractive therapeutic target for DN. Twit Text FOAVip Diacylglycerol Kinase alpha is Involved in the Vitamin E-Induced Amelioration of Diabetic Nephropathy in Mice ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28572624 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28572624 #FOAvip English Wikipedia <ref>{{Cite pmid|28572624 }}</ref> Diacylglycerol Kinase alpha is Involved in the Vitamin E-Induced Amelioration of Diabetic Nephropathy in Mice #MMPMID28572624 Hayashi D ; Yagi K ; Song C ; Ueda S ; Yamanoue M ; Topham M ; Suzaki T ; Saito N ; Emoto N ; Shirai Y Sci Rep 2017[Jun]; 7 (1 ): 2597 PMID28572624 show ga Diabetic nephropathy (DN) is one of vascular complications of diabetes and is caused by abnormal protein kinase C activation as a result of increased diacylglycerol (DG) production in diabetic hyperglycaemia. Diacylglycerol kinase (DGK) converts DG into phosphatidic acid. Therefore, it is expected that the activation of DGK would ameliorate DN. Indeed, it has been reported that vitamin E (VtE) ameliorates DN in rat by activating DGK, and we recently reported that VtE specifically activates DGK? isoform in vitro. However, whether DGK? is involved in the VtE-induced amelioration of DN in vivo remains unknown. Therefore, we investigated the VtE-induced amelioration of DN in wild-type (DGK?(+/+)) and DGK?-deficient (DGK?(-/-)) mice in which diabetes was induced by streptozocin. Several symptoms of DN were ameliorated by VtE treatment in the DGK?(+/+) mice but not in the DGK?(-/-) mice. Moreover, transmission electron microscopy of glomeruli and immunofluorescent staining of glomerular epithelial cells (podocytes) indicated that VtE ameliorates podocyte pathology and prevents podocyte loss in the DGK?(+/+) mice but not in the DGK?(-/-) mice. We showed that VtE can ameliorate DN in mice and that DGK? is involved in the VtE-induced amelioration of DN in vivo, suggesting that DGK? is an attractive therapeutic target for DN. |Animals [MESH] |Cells, Cultured [MESH] |Diabetes Mellitus, Experimental/*drug therapy/metabolism [MESH] |Diabetic Nephropathies/*drug therapy/metabolism [MESH] |Diacylglycerol Kinase/*metabolism [MESH] |Disease Models, Animal [MESH] |Humans [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Molecular Targeted Therapy [MESH] |Podocytes/*pathology [MESH] |Rats [MESH]Diacylglycerol Kinase alpha is Involved in the Vitamin E-Induced Ameli(epmc).pdf DeepDyve Pubget Overpricing