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10.1177/0271678X16655550 http://scihub22266oqcxt.onion/10.1177/0271678X16655550 C5453458!5453458 !27306753     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27306753 &cmd=llinks): Failed to open stream: HTTP request failed! 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Paravascular channels, cisterns, and the subarachnoid space in the rat brain: A single compartment with preferential pathways |pdf=|usr=}}{{27306753 }} gab.com Text Paravascular channels, cisterns, and the subarachnoid space in the rat brain: A single compartment with preferential pathways JO: J Cereb Blood Flow Metab http://www.kidney.de/pget.php?&tw=1&pmid=27306753 #FOAvip Recent evidence suggests an extensive exchange of fluid and solutes between the subarachnoid space and the brain interstitium, involving preferential pathways along blood vessels. We studied the anatomical relations between brain vasculature, cerebrospinal fluid compartments, and paravascular spaces in male Wistar rats. A fluorescent tracer was infused into the cisterna magna, without affecting intracranial pressure. Tracer distribution was analyzed using a 3D imaging cryomicrotome, confocal microscopy, and correlative light and electron microscopy. We found a strong 3D colocalization of tracer with major arteries and veins in the subarachnoid space and large cisterns, attributed to relatively large subarachnoid space volumes around the vessels. Confocal imaging confirmed this colocalization and also revealed novel cisternal connections between the subarachnoid space and ventricles. Unlike the vessels in the subarachnoid space, penetrating arteries but not veins were surrounded by tracer. Correlative light and electron microscopy images indicated that this paravascular space was located outside of the endothelial layer in capillaries and just outside of the smooth muscle cells in arteries. In conclusion, the cerebrospinal fluid compartment, consisting of the subarachnoid space, cisterns, ventricles, and para-arteriolar spaces, forms a continuous and extensive network that surrounds and penetrates the rat brain, in which mixing may facilitate exchange between interstitial fluid and cerebrospinal fluid. Twit Text FOAVip Paravascular channels, cisterns, and the subarachnoid space in the rat brain: A single compartment with preferential pathways ????J Cereb Blood Flow Metab http://www.kidney.de/pget.php?&tw=1&pmid=27306753 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27306753 #FOAvip English Wikipedia <ref>{{Cite pmid|27306753 }}</ref> Paravascular channels, cisterns, and the subarachnoid space in the rat brain: A single compartment with preferential pathways #MMPMID27306753 Bedussi B ; van der Wel NN ; de Vos J ; van Veen H ; Siebes M ; VanBavel E ; Bakker EN J Cereb Blood Flow Metab 2017[Apr]; 37 (4 ): 1374-1385 PMID27306753 show ga Recent evidence suggests an extensive exchange of fluid and solutes between the subarachnoid space and the brain interstitium, involving preferential pathways along blood vessels. We studied the anatomical relations between brain vasculature, cerebrospinal fluid compartments, and paravascular spaces in male Wistar rats. A fluorescent tracer was infused into the cisterna magna, without affecting intracranial pressure. Tracer distribution was analyzed using a 3D imaging cryomicrotome, confocal microscopy, and correlative light and electron microscopy. We found a strong 3D colocalization of tracer with major arteries and veins in the subarachnoid space and large cisterns, attributed to relatively large subarachnoid space volumes around the vessels. Confocal imaging confirmed this colocalization and also revealed novel cisternal connections between the subarachnoid space and ventricles. Unlike the vessels in the subarachnoid space, penetrating arteries but not veins were surrounded by tracer. Correlative light and electron microscopy images indicated that this paravascular space was located outside of the endothelial layer in capillaries and just outside of the smooth muscle cells in arteries. In conclusion, the cerebrospinal fluid compartment, consisting of the subarachnoid space, cisterns, ventricles, and para-arteriolar spaces, forms a continuous and extensive network that surrounds and penetrates the rat brain, in which mixing may facilitate exchange between interstitial fluid and cerebrospinal fluid. |*Brain/blood supply/diagnostic imaging/ultrastructure [MESH] |*Cisterna Magna/diagnostic imaging/ultrastructure [MESH] |Animals [MESH] |Blood Vessels/*diagnostic imaging/ultrastructure [MESH] |Cerebral Ventricles/blood supply/diagnostic imaging/ultrastructure [MESH] |Cerebrospinal Fluid/*diagnostic imaging [MESH] |Dextrans [MESH] |Endothelium, Vascular/diagnostic imaging/ultrastructure [MESH] |Extracellular Fluid/diagnostic imaging [MESH] |Imaging, Three-Dimensional/*methods [MESH] |Male [MESH] |Microscopy, Confocal [MESH] |Microscopy, Electron [MESH] |Rats, Inbred WKY [MESH]Paravascular channels, cisterns, and the subarachnoid space in the rat(epmc).pdf DeepDyve Pubget Overpricing